Scientific publications

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Estrategia no farmacológica del deterioro cerebral senil y demencia.
Medicine 1994; 6:44-53
Ll. Tárraga Mestre

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Epidemilología de los Trastornos Cognitivos en Población Geriátrica Internada en Centros Socio-Sanitarios de Barcelona Ciudad.
Rev Neurol. 1995 Jan-Feb; doi:23(119):174-80.
Boada M., Tárraga L., Monteserín R., Nebot C., Canela J. 

Epidemiología de los Trastornos Cognitivos en la Población Geriátrica de los “Casals d’Avis” de Barcelona Ciudad.
Rev Neurol. 1995 Jan-Feb; doi:23(119):166-73.
Boada M, Tarraga L, Monteserin R, Nebot C, Canela J.

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El papel de las unidades de diagnóstico y evaluación de los trastornos cognitivos y de la conducta ante el diagnóstico precoz de la enfermedad de Alzheimer. Análisis de 962 casos consecutivos, período 1996-1998 Fundación ACE. 
Revista de Neurología, 27 (Supl 1): S5 – S15
Boada, M. 
 
A neuropsychological and global study of cognitive impairment and dementia (CID) in the catalonian geriatric institutionalized subjects. 
Journal of Clinical Epidemiology 1998, Volume 51, Supp, 19S.
Boada M, Tárraga L, Monteserín R, Hernández I, Juncà S, Patricio F, Abós-Herrándiz R, Canela-Soler J.

Estimated cost of Alzheimer's Disease (AD) in community patients in Spain: Preliminary results. 
Journal of Clinical Epidemiology 1998, Volume 51, Supp 1, 31S.
Boada M, Bermejo F, Peña J, Espinosa C, Bayer QF, Hart WM, Soykos SL, Tárraga L, Abós-Herrándiz R, Canela-Soler J. 

Terapias blandas: Programa de Psicoestimulación Integral. Alternativa terapéutica para las personas con enfermedad de Alzheimer. 
Rev Neurol. 1998; doi:27:51-01
L. Tárraga-Mestre.

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Coste de los servicios de los pacientes en régimen ambulatorio diagnosticados de enfermedad de Alzheimer en España. 
Med Clin (Barc). 1999 Nov 27;113(18):690-5. PDF
Peña-Casanova J, Bermejo F, Guillén F, Hart WM, Espinosa C, Rovira J.

El tratamiento longitudinal de la enfermedad de Alzheimer. Del envejecimiento a la enfermedad de Alzheimer. 
Continua Neurológica, vol 1 (1): 82-106.
Boada, M., Tárraga, L.

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Enfermedad de Alzheimer y medicina basada en la evidencia. Dispositivos asistenciales en la enfermedad de Alzheimer desde la perspectiva de la medicina basada en la evidencia. 
Revista Neurología, Vol. 15. Suplemento 4, 64 – 78.
Boada M.

Review of Creutzfeldt-Jakob disease and other prion diseases.
Rev Neurol. 2000 Dec; doi:31(12):1171-9.
Zivkovic S, Boada M, Lopez O.

Hypertrophic pachymeningitis. A review of the histories of two cases and pathological relationship with the Tolosa-Hunt syndrome and the orbital pseudotumor.
Rev Neurol. 2000 Nov; doi:31(10):946-51.
Bosch J, Ortega-Aznar A, Tintore M, Rio J, Ferreira R, Rubio E, Rovira A, Abilleira S, Mauleon A, Montalban X, Boada M, Codina A .

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Estrategias terapéuticas en la enfermedad de Alzheimer: concepto ad continuum. 
Rev Neurol. 2001 Jun; doi:32(11):1074-84.
Boada M. 

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Neuropsychiatric Inventory Questionnaire (NPI-Q): Validación española  de una forma abreviada del Neuropsychiatric Inventory (NPI). 
Neurología, 2002:17(6):317-323.
Boada M, Cejudo JC, Tárraga L, López O, Kaufer D. (2002. 

Apolipoprotein E Christchurch in a family with Alzheimer's disease and altered lipid values.
Alzheimers Rep. 5:17-20. PDF
Bertranpetit J., Comas D. 

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Ubiquitin-negative mini-pick-like bodies in the dentate gyrus in P301L Tauopathy. 
J Alzheimers Dis. 2003 Dec; doi:5(6):445-54.
Ferrer I., Hernández I., Puig B., Rey M.J., Ezquerra M., Tolosa E., Boada M. 

Las necesidades informativas sobre la salud en internet. 
Comunicación y Cultura núm.27:33-35. Free full text
Quark. Ciencia, Medicina.

Subacute Meningoencephalitis in a subset of patients with AD after Aß42 immunization 
Neurology 2003; 61:46-54. PDF
Orgogozo JM1, Gilman S, Dartigues JF, Laurent B, Puel M, Kirby LC, Jouanny P, Dubois B, Eisner L, Flitman S, Michel BF, Boada M, Frank A, Hock C.

Primary Progressive Aphasia as the initial manifestation of corticobasal degeneration and unusual tauoptahies. 
Acta Neuropathol. 2003 Nov; doi:106(5):419-35.
Ferrer I., Hernández I., Boada M., Llorente A., Rey M.J., Cardozo A., Ezquerra M., Puig B.

Possible increased risk for Alzheimer's disease associated with neprilysin gene.
J Neural Transm (Vienna). 2003 Jun; doi:110(6):651-7.
Clarimón J, Muñoz FJ, Boada M, Tárraga L, Sunyer J, Bertranpetit J, Comas D.

HSP70-2 (HSPA1B) is associated with noncognitive symptoms in late onset Alzheimer’s disease. 
J Geriatr Psychiatry Neurol. 2003 Sep; doi:16(3):146-50.
Boada M., Tárraga L., Comas D.

Joint analysis of candidate genes related to Alzheimer's disease in a Spanish population. 
Psychiatr Genet. 2003 Jun; doi:13(2):85-90.
Clarimón J, Bertranpetit J, Calafell F, Boada M, Tàrraga L, Comas D (2003).

Association study between Alzheimer’s disease and different genes involved in Aβ biosynthesis, aggregation and degradation: positive results with BACE1. 
J Neurol 250:956-961.
Clarimón J., Bertranpetit J., Calafell F., Boada M., Tárraga L., Comas D.

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El documento de voluntades anticipadas y la relación neurólogo-paciente.
Neurología 2004;19(Supl 4):52-59. PDF
Boada Rovira M. 

Lo que cuestan las demencias. En: Alzheimer 2004: La pragmática necesaria. 
Ediciones Aula Médica; 2004:2:13-24.
Boada Rovira, M. 

Estudi de la qualitat visual en adults amb síndrome de Down.
Revista mèdica internacional sobre la Síndrome de Down 2004: vol. 8, núm. 1, pp. 2-7. 
Castañé M, Boada M, Hernández I. 

Familial Alzheimer disease associated with A713T mutation in APP. 
Neurosci Lett. 2004 Nov 11; doi:370(2-3):241-3.
Armstrong J, Boada M, Rey MJ, Vidal N, Ferrer I. 

Neuropathology and Pathogenetics of encephalitis following Amyloid-β Immunization in Alzheimer’s Disease. 
Brain Pathology 2004 Jan; doi:14(1):11-20.
Ferrer I, Boada M, Sánchez ML, Rey MJ, Costa-Jussá F. 

Trastornos oculares propios del Síndrome de Down en mayores de 40 años.
Revista de Neurología 2004; doi:39(11):1017-1021. Free full text
Castañé M., Boada M., Hernández I. 

Demencia Senil y Enfermedad de Alzheimer. En: Manual de recomendaciones nutricionales en pacientes geriátricos.
Planas Vilà M. Editores Médicos, S.A.; 2004:121-128.
Boada Rovira, M.

Micronutrient supplementation in mild Alzheimer disease patients.
Clin Nutr. 2004 Apr; doi:23(2):265-72.
Planas M., Conde M., Audivert S., Pérez-Portabella C., Burgos R., Chacón P., Rosselló J., Boada M., Tárraga Ll.

Efficacy and Safety of Donepezil in Patients with Alzheimer’s Disease. Results of a Global, Multinational, Clinical Experience Study. 
Drugs Aging. 2004; doi:21(1):43-53.
Boada Rovira, M., Brodaty H., Cras P., Baloyannis S., Emre M., 322 Study Group, Zhang R, Bahra R.

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Etude sur la qualité de la vue chez les adultes porteuses d’un syndrome de Down. 
Journal de la Trisomie 21 2005; doi:14:16-21
Castañé M, Boada M, Hernández I.

Estudio clinicoterapéutico de la demencia en las personas con síndrome de Down y eficacia del donepecilo en esta población. 
L. Revista de Neurología, 2005; Vol. 41(3): 129-136. Free full text
Boada-Rovira M, Hernández-Ruiz I, Badenas-Homiar S, Buendía-Torras M, Tárraga-Mestre.

Human plasma semicarbazide sensitive amine oxidase (SSAO) β-Amyloid protein and aging.
Neurosciences Letters. 2005; doi:384:183-187
Hernández M, Esteban M, Szabo P, Boada M, Unzeta M. 

Neuropsychiatric Inventory-Nursing Home Version (NPI-NH): Validación española.
Neurología 2005; doi:20(10): 665-673, PDF
Boada M, Tárraga L, Modinos G, López OL, Cummings JL.
Clinical effects of Aβ immunization (AN1792) in patients with Alzheimer Disease in an interrupted trial. 
Neurology 2005; doi:64:1553-62
Gilman S, Koller M, Black RS, Jenkins L, Griffith SG, Fox NC, Eisner L, Kirby L, Boada M, Forette F, Orgogozo JM; for the AN1792(QS-21)-201 Study team. 

Effects of Aβ immunization (AN1792) on MRI measures of cerebral volume in Alzheimer Disease. 
Neurology 2005; doi:64: 1563-1572.  PDF.
Fox NC, Black RS, Gilman S, Rossor MN, Griffith SG, Jenkins L, Koller M; for the AN1792(QS-21)-201 Study team.

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Health and nutritional promotion program for patients with dementia (NutriAlz Study): rando and baseline data
J Nutr Health Aging. 2009 Jun; I.F.:  2.68  doi:13(6):529-37.
Salva A, Andrieu S, Fernandez E, Schiffrin EJ, Moulin J, Decarli B, Guigoz Y, Vellas B; NutriAlz Group.
 
Amyloid-targeted in Alzheimer’s Disease: Use of human albumin in plasma Exchange as a novel approach for Aβ mobilization 
Drug News Perspect. 2009 Jul-Aug;22(6):325-39. doi: 10.1358/dnp.2009.22.6.1395256.
Boada M, Ortiz P, Anaya F, Hernández I, Muñoz J, Núñez L, Olazarán J, Roca I, Cuberas G, Tárraga L, Buendia M, Pla RP, Ferrer I, Páez A.

Creating a transatlantic research enterprise for preventing Alzheimer’s disease
Alzheimers Dement. 2009 Jul;5(4):361-6.  I.F.:  6.37   doi: 10.1016/j.jalz.2009.05.158.
Khachaturian ZS, Camí J, Andrieu S, Avila J, Boada M, Breteler M, Froelich L, Gauthier S, Gómez-Isla T, Khachaturian AS, Kuller LH, Larson EB, Lopez OL, Martinez-Lage JM, Petersen RC, Schellenberg GD, Sunyer J, Vellas B, Bain LJ.

Creating a transatlantic research enterprise for preventing Alzheimer’s disease
Alzheimers Dement. 2009 Jul;5(4):361-6.  I.F.:  6.37   doi: 10.1016/j.jalz.2009.05.158.
Khachaturian ZS, Camí J, Andrieu S, Avila J, Boada M, Breteler M, Froelich L, Gauthier S, Gómez-Isla T, Khachaturian AS, Kuller LH, Larson EB, Lopez OL, Martinez-Lage JM, Petersen RC, Schellenberg GD, Sunyer J, Vellas B, Bain LJ.

Long-Term Follow-Up of Patients Immunized with AN1792: Reduced Functional Decline in Antibody Responders 
Curr Alzheimer Res. 2009 Apr;   I.F.: 4,97  doi:6(2):144-51.
Vellas B, Black R, Thal LJ, Fox NC, Daniels M, McLennan G, Tompkins C, Leibman C, Pomfret M, Grundman M; AN1792 (QS-21)-251 Study Team.

Detection of visuoperceptual deficits in preclinical and mild Alzheimer’s disease
J Clin Exp Neuropsychol. 2009 Oct;31(7):860-7.  I.F.: 1,77   doi: 10.1080/13803390802595568. Epub 2009 Jan 14.
Alegret M, Boada-Rovira M, Vinyes-Junqué G, Valero S, Espinosa A, Hernández I, Modinos G, Rosende-Roca M, Mauleón A, Becker JT, Tárraga L. 

Neuronal TIMP-1 release accompanies astrocytic MMP-9 secretion and enhances astrocyte proliferation induced by B-amyloid 25-35 fragment 
J Neurosci Res. 2009 Jul;87(9):2115-25.  I.F.: 2,99   doi: 10.1002/jnr.22034.
Hernández-Guillamon M, Delgado P, Ortega L, Pares M, Rosell A, García-Bonilla L, Fernández-Cadenas I, Borrell-Pagès M, Boada M, Montaner J. 

Ecological assessment of executive functions in Mild Cognitive Impairment and mild Alzheimer’s Disease 
J Int Neuropsychol Soc. 2009 Sep;15(5):751-7.  I.F.:  2,77    doi: 10.1017/S135561770999035X. Epub 2009 Jul 2.
Espinosa A, Alegret M, Boada M, Vinyes G, Valero S, Martínez-Lage P, Peña-Casanova J, Becker JT, Wilson BA, Tárraga L.

GAB2 gene does not modify of Alzheimer’s disease in Spanish APOE 4 carriers
J Nutr Health Aging. 2009 Mar;  I.F.: 1,71  doi:13(3):214-9.
Ramírez-Lorca R, Boada M, Sáez M E, Hernández I, Mauleón A, Rosende-Roca M, Martínez-Lage P, Gutiérrez M, Real LM, López-Arrieta J, Gayán J, Antúnez C, González-Pérez A, Tárraga L, Ruiz A.

A diet enriched in polyphenols and polyun saturated fatty acids, LMN diet, induces neurogenesis in the subventricular zone and hippocampus of adult mouse brain
J Alzheimers Dis. 2009;18(4):849-65.  I.F.: 4,26    doi: 10.3233/JAD-2009-1188.
Valente T, Hidalgo J, Bolea I, Ramirez B, Anglés N, Reguant J, Morelló JR, Gutiérrez C, Boada M, Unzeta M. 

Prefrontal córtex volume reduction on MRI in preclinical Huntington’s disease relates to visuomotor performance and CAG number
Parkinsonism Relat Disord. 2009 Mar;15(3):213-9.  I.F.:  3.79   doi: 10.1016/j.parkreldis.2008.05.010. Epub 2008 Jul 15.
Gómez-Ansón B, Alegret M, Muñoz E, Monté GC, Alayrach E, Sánchez A, Boada M, Tolosa E.

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Estrogen receptor alpha gene variants are associated with Alzheimer’s disease
Neurobiol Aging. 2012 Jan; I.F.: 6.19  doi:33(1):198.e15-24.
Boada M, Antunez C, López-Arrieta J, Caruz A, Moreno-Rey C, Ramírez-Lorca R, Morón FJ, Hernández I, Mauleón A, Rosende-Roca M, Martínez-Lage P, Marín J, Tárraga L, Alegret M, Pedrajas JR, Urda N, Royo JL, Saez ME, Gayán J, González-Pérez A, Real LM, Ruiz A, Galán JJ.

CALHM86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer’s disease : A Meta-Analysis Study
J Alzheimers Dis 2010; I.F.: 4,26  doi:22(1):247-255.
Lambert JC, Sleegers K, González-Pérez A, Ingelsson M, Beecham GW, Hiltunen M, Combarros O, Bullido MJ, Brouwers N, Bettens K, Berr C, Pasquier F, Richard F, Dekosky ST, Hannequin D, Haines JL, Tognoni G, Fiévet N, Dartigues JF, Tzourio C, Engelborghs S, Arosio B, Coto E, De Deyn P, Del Zompo M, Mateo I, Boada M, Antunez C, Lopez-Arrieta J, Epelbaum J, Schjeide BM, Frank-Garcia A, Giedraitis V, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri R, Delepine M, Zelenika D, Lathrop M, Scarpini E, Siciliano G, Solfrizzi V, Sorbi S, Spalletta G, Ravaglia G, Valdivieso F, Vepsäläinen S, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossù P, Hanon O, Piccardi P, Annoni G, Mann D, Marambaud P, Seripa D, Galimberti D, Tanzi RE, Bertram L, Lendon C, Lannfelt L, Licastro F, Campion D, Pericak-Vance MA, Soininen H, Van Broeckhoven C, Alpérovitch A, Ruiz A, Kamboh MI, Amouyel P. J Alzheimers Dis

Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-beta E22Q and L34V mutants, delaying their toxicity for human brain microvascular endothelial cells
J Biol Chem. 2010 Aug 27;285(35):27144-58. I.F.: 4.77  doi: 10.1074/jbc.M110.135228. Epub 2010 Jun 24.
Hernandez-Guillamon M, Mawhirt S, Fossati S, Blais S, Pares M, Penalba A, Boada M, Couraud PO, Neubert TA, Montaner J, Ghiso J, Rostagno A.

Regional variation on the presentation of AD patients in memory clinics within Europe – data from the ICTUS study 
J Alzheimers Dis. 2010;21(1):155-65.  I.F.: 4,26  doi: 10.3233/JAD-2010-091489
Hausner L, Frölich L., Gardette V, Reynish E, Ousset PJ, Andrieu S2), Vellas B, on behalf of the ICTUS-EADC study group. 

Albúmina en la plasmaféresis: una nueva terapia de movilización del beta amiloide en la enfermedad de Alzheimer
Rev Neurol 2010; I.F.: 0.65  doi:50(Supl. 5):S9-S18]
Boada M.  

Willingness-to-pay for reductions in care need: estimating the value of informal care in Alzheimer’s disease
Int J Geriatr Psychiatry 2010;  I.F.: 2.41  doi:25:622-632.
Gustavsson A, Jönsson L, McShane R, Boada M, Wimo A, Zbrozek AS.

Genome-wide Analysis of Genetic Loci Associated With Alzheimer’s Disease
JAMA. 2010 May 12;  I.F.: 30.03  doi:303(18):1832-40.
Seshadri S, Fitzpatrick AL, Ikram MA, DeStefano AL, Gudnason V, Boada M, Bis JC, Smith AV, Carassquillo MM, Lambert JC, Harold D, Schrijvers EM, Ramirez-Lorca R, Debette S, Longstreth WT Jr, Janssens AC, Pankratz VS, Dartigues JF, Hollingworth P, Aspelund T, Hernandez I, Beiser A, Kuller LH, Koudstaal PJ, Dickson DW, Tzourio C, Abraham R, Antunez C, Du Y, Rotter JI, Aulchenko YS, Harris TB, Petersen RC, Berr C, Owen MJ, Lopez-Arrieta J, Varadarajan BN, Becker JT, Rivadeneira F, Nalls MA, Graff-Radford NR, Campion D, Auerbach S, Rice K, Hofman A, Jonsson PV, Schmidt H, Lathrop M, Mosley TH, Au R, Psaty BM, Uitterlinden AG, Farrer LA, Lumley T, Ruiz A, Williams J, Amouyel P, Younkin SG, Wolf PA, Launer LJ, Lopez OL, van Duijn CM, Breteler MM; CHARGE Consortium; GERAD1 Consortium; EADI1 Consortium.

CALHM1 P86L polymorphism is associated to late-onset Alzheimer’s disease in a recessive model 
J Alzheimers Dis. 2010 Apr;  I.F.: 4,26  doi:20(1):247-51.
Boada M, Antúnez C, López-Arrieta J, Galán JJ, Morón FJ, Hernández I, Marín J, Martínez-Lage P, Alegret M, Carrasco JM, Moreno C, Real LM, González-Pérez A, Tárraga L, Ruiz A. 

Genetic screening of Alzheimer’s disease genes in Iberian and African samples yields novel mutations in presenilins and APP
J. Neurobiol Aging. 2010 May;  I.F.: 5,94  doi:31(5):725-731. 
Guerreiro RJ, Baquero M, Blesa R, Boada M, Brás JM, Bullido MJ, Calado A, Crook R, Ferreira C, Frank A, Gómez-Isla T, Hernández I, Lleó A, Machado A, Martínez-Lage P, Masdeu J, Molina-Porcel L, Molinuevo JL, Pastor P, Pérez-Tur J, Relvas R, Oliveira CR, Ribeiro MH, Rogaeva E, Sa A, Samaranch L, Sánchez-Valle R, Santana I, Tárraga L, Valdivieso F, Singleton A, Hardy J, Clarimón

Brain perfusion correlates of visuoperceptual deficits in preclinical and mild Alzheimer disease 
J Alzheimers Dis 21 (2010) 557-567. I.F.: 4,26
Alegret M, Vinyes-Junqué G, Boada M, Martínez-Lage P, Cuberas G, Espinosa A, Roca I, Hernández I, Valero S, Rosende-Roca M, Mauleón A, Becker JT, Tárraga L.  

Diagnóstico y evolución de la degeneración lobular fronto-temporal en una unidad de demencias: 12 años de experiencia 
Alzheimer Real Invest Demenc 2010;44:5-14.
Hernández I, Martínez-Lage P, Valero S, Alegret M, Rey MJ, Espinosa A, Mauleón A, Viñas G, Rosende-Roca M, Tárraga L, Boada M.  

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Do Instrumental Activities of Daily Living Predict Dementia at 1- and 2-Year Follow-Up? Findings from the Development of Screening Guidelines and Diagnostic Criteria for Predementia Alzheimer’s Disease Study
J Am Geriatr Soc. 2011 Dec;59(12):2273-81.  I.F.: 3,98   doi: 10.1111/j.1532-5415.2011.03732.x.
Sikkes SA, Visser PJ, Knol DL, de Lange-de Klerk ES, Tsolaki M, Frisoni GB, Nobili F, Spiru L, Rigaud AS, Frölich L, Rikkert MO, Soininen H, Touchon J, Wilcock G, Boada M, Hampel H, Bullock R, Vellas B, Pijnenburg YA, Scheltens P, Verhey FR, Uitdehaag BM.

No evidence of APP point mutations and locus duplication in individuals with cerebral amyloid angiopathy
Eur J Neurol. 2011 Oct;18(10):1279-81.   I.F.: 3.69   doi: 10.1111/j.1468-1331.2011.03401.x. Epub 2011 Apr 4.
Domingues-Montanari S, Parés M, Hernández-Guillamon M, Fernández-Cadenas I, Mendioroz M, Ortega G, Boada M, Masjuan J, Huertas N, Alvarez-Sabín J, Delgado P, Montaner J; Stroke Project of Cerebrovascular Diseases Study Group, Spanish Society of Neurology. 

Evaluación de la conveniencia del cambio de vía de administración de Rivastigmina en pacientes con enfermedad de Alzheimer
Neurologia.2011; I.F.: 0.79  doi:26 :262-71 - vol.26 núm 05
Blesa R, Boada M, Martínez C, Gil-Saladié D, Antúnez C, Gobatt AL, Grupo KAPA.

Genetic association of CR1 polymorphism rs3818361 in Alzheimer's disease 
Alzheimers Dement. 2011 Jul;7(4):e124-9.  I.F.: 6.37  doi: 10.1016/j.jalz.2011.05.2412.
Antúnez C , Boada M, López-Arrieta J, Moreno-Rey C, Hernández I, Marín J, Gayán J, González-Pérez A, Real LM, Alegret M, Tárraga L, Ramírez-Lorca R, Ruiz A, and the Alzheimer’s Disease Neuroimaging Initiative. 

The MTHFD1L gene rs11754661 marker is not associated with Alzheimer's disease: evidence from a sample of the Spanish population
J Alzheimers Dis. 2011;25(1):47-50. I.F.: 4,26  doi: 10.3233/JAD-2011-101983.
Ramírez-Lorca R, Boada M, Antúnez C, López-Arrieta J, Moreno-Rey, Hernández I,  Juan Marín J, Gayán J, González-Pérez A, Alegret M, Tárraga L, Real L.M.,  Ruiz A

Activation of PKR Causes Amyloid ß-Peptide Accumulation Via De-Repression of BACE1 Expression 
PLoS One. 2011;6(6):e21456.  I.F.: 4.09  doi: 10.1371/journal.pone.0021456. Epub 2011 Jun 28.
Ill-Raga G, Palomer E, Wozniak MA, Ramos-Fernández E, Bosch-Morató M, Tajes M, Guix FX, Galán JJ, Clarimón J, Antúnez C, Real LM, Boada M, Itzhaki RF, Fandos C, Muñoz FJ.

The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's Disease
Genome Med. 2011 May I.F.: 5.25  doi:31;3(5):33. 
Antúnez C, Boada M, González-Pérez A, Gayán J, Ramírez-Lorca R, Marín J, Hernández I, Moreno-Rey C, Morón FJ, López-Arrieta J, Mauleón A, Rosende-Roca M, Noguera-Perea F, Legaz-García A, Vivancos-Moreau L, Velasco J, Carrasco JM, Alegret M, Antequera-Torres M, Manzanares S, Romo A, Blanca I, Ruiz S, Espinosa A, Castaño S, García B, Martínez-Herrada B, Vinyes G, Lafuente A, Becker JT, Galán JJ, Serrano-Ríos M; Alzheimer's Disease Neuroimaging Initiative, Vázquez E, Tárraga L, Sáez ME, López OL, Real LM, Ruiz A. 

Clinical features and APOE genotype of pathologically proven early-onset Alzheimer’s disease 
Neurology. 2011 May 17;76(20):1720-5.  I.F.: 8.31   doi: 10.1212/WNL.0b013e31821a44dd
Balasa M, Gelpi E, Antonell A, Rey MJ, Sánchez-Valle R, Molinuevo JL, Lladó A; Neurological Tissue Bank/University of Barcelona/Hospital Clínic NTB/UB/HC Collaborative Group.

ACE variants and risk of intracerebral hemorrhage recurrence in amyloid angiopathy
Neurobiol Aging. 2011 Mar;32(3):551.e13-22.  I.F.: 6,19  doi: 10.1016/j.neurobiolaging.2010.01.019. Epub 2010 Apr 9.
Domingues-Montanari S, Hernandez-Guillamon M, Fernandez-Cadenas I, Mendioroz M, Boada M, Munuera J, Rovira A, Maisterra O, Parés M, Gutierrez M, Alvarez-Sabin J, Chacón P, Delgado P, Montaner J; Stroke Project Cerebrovascular Diseases Study Group, Spanish Society of Neurology. 

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Exploratory analysis of seven Alzheimer’s disease genes: disease progression
Neurobiol Aging. 2013 Apr;34(4):1310.e1-7. I.F.: 6.19  doi: 10.1016/j.neurobiolaging.2012.08.01 Epub 2012 Oct 1.
Ruiz A, Hernández I, Rosende-Roca M, González-Pérez A, Rodríguez-Noriega E, Ramírez-Lorca R, Mauleón A, Moreno-Rey C, Boswell L, Tune L, Valero S, Alegret M, Gayán J, Becker JT, Real LM, Tárraga L, Ballard C, Terrin ML, Sherman S, Payami H, López OL, Mintzer JE, Boada M. 

Progression of Alzheimer disease in Europe: Data from the European ICTUS study
Curr Alzheimer Res. 2012 Oct;  I.F.: 3.95  doi:9(8):902-12.
Vellas B, Hausner L, Frölich L, Cantet C, Gardette V, Reynish E, Gillette S, Agüera-Morales E, Auriacombe S, Boada M, Bullock R, Byrne J, Camus V, Cherubini A, Eriksdotter-Jönhagen M, Frisoni GB, Hasselbalch S, Jones RW, Martinez-Lage P, Rikkert MO, Tsolaki M, Ousset PJ, Pasquier F, Ribera-Casado JM, Rigaud AS, Robert P, Rodriguez G, Salmon E, Salva A, Scheltens P, Schneider A, Sinclair A, Spiru L, Touchon J, Zekry D, Winblad B, Andrieu S. 

Reliable Measurements of the β-Amyloid Pool in Blood Could Help in the Early Diagnosis of AD 
Int J Alzheimers Dis. 2012;  doi: 2012:604141. Epub 2012 Aug 16.
Pesini P, Pérez-Grijalba V, Monleón I, Boada M, Tárraga L, Martínez-Lage P, San-José I, Sarasa M.

Investigation of C9orf72 in 4 Neurodegenerative Disorders
Arch Neurol. 2012 Dec;69(12):1583-90.  I.F.: 6,19   doi: 10.1001/archneurol.2012.2016.
Xi Z, Zinman L, Grinberg Y, Moreno D, Sato C, Bilbao JM, Ghani M, Hernández I, Ruiz A, Boada M, Morón FJ, Lang AE, Marras C, Bruni A, Colao R, Maletta RG, Puccio G, Rainero I, Pinessi L, Galimberti D, Morrison KE, Moorby C, Stockton JD, Masellis M, Black SE, Hazrati LN, Liang Y, van Haersma de With J, Fornazzari L, Villagra R, Rojas-Garcia R, Clarimón J, Mayeux R, Robertson J, St George-Hyslop P, Rogaeva E. 

Efficacy of Souvenaid in Mild Alzheimer’s Disease: Results from a Randomized, Controlled Trial 
J Alzheimers Dis. 2012;31(1):225-36. I.F.: 4,26  doi: 10.3233/JAD-2012-121189.
Scheltens P, Twisk JW, Blesa R, Scarpini E, von Arnim CA, Bongers A, Harrison J, Swinkels SH, Stam CJ, de Waal H, Wurtman RJ, Wieggers RL, Vellas B, Kamphuis PJ. 
Boada M.: cited as contributor

Molecular evaluation of human Ubiquilin 2 gene PXX domain in familial Frontotemporal dementia patients 
J Neurol. 2012 Nov;259(11):2488-90.  I.F.: 3.47   doi: 10.1007/s00415-012-6568-5. Epub 2012 Jun 24.
Hernández I, Espinosa A, Real LM, Galán JJ, Mauleón A, Roca MR, Tárraga L, Ruiz A, Boada M.

La investigación en los procedimientos de incapacidad de las personas con enfermedades neurodegenerativas que cursan con demencia
Rev Esp Med Legal. 2012;  I.F.: 0.22   doi:38(3):89-90
Josep Arimany-Manso, Esperanza L. Gómez-Durán, Mercè Boada, Silvia Ventura Mas, Lluís Tárraga, Dolors Clos Masó y Jorge Matías-Guiu. 

Expansion mutation in C9ORF72 does not influence plasma progranulin levels in frontotemporal dementia 
Neurobiol Aging. 2012 Aug;33(8):1851.e17-9.  I F: 6,19    doi: 10.1016/j.neurobiolaging.2012.03.005Epub 2012 Apr 11.
Dols-Icardo O, Suárez-Calvet M, Hernández I, Amer G, Antón-Aguirre S, Alcolea D, Fortea J, Boada M, Tárraga L, Blesa R, Lleó A, Clarimón

A Two-Year Follow-Up of Cognitive Deficits and Brain Perfusion in Mild Cognitive Impairment and Mild Alzheimer's Disease 
J Alzheimers Dis. 2012;30(1):109-20. I.F.: 4.26  doi: 10.3233/JAD-2012-111850.
Alegret M, Cuberas-Borrós G, Vinyes-Junqué G, Espinosa A, Valero S, Hernández I, Roca I, Ruíz A, Rosende-Roca M, Mauleón A, Becker JT, Castell-Conesa J, Tárraga L, Boada M.

LMN diet, rich in polyphenols and polyunsaturated fatty acids, improves mouse cognitive decline associated to aging and Alzheimer`s disease 
Behav Brain Res. 2012 Mar 17;228(2):261-71.  I.F.: 3.39   doi: 10.1016/j.bbr.2011.11.014. Epub 2011 Nov 22.
Fernández-Fernández L, Comes G, Bolea I, Valente T, Ruiz J, Murtra P, Ramirez B, Anglés N, Reguant J, Morelló JR, Boada M, Hidalgo J, Escorihuela RM, Unzeta M. 

A pilot study of the effects of internet-based cognitive stimulation on neuropsychological function in HIV disease
Disabil Rehabil. 2012;34(21):1848-52.  I.F.: 1.49    doi: 10.3109/09638288.2012.667188. Epub 2012 Mar 30.
Becker JT., Dew MA, Aizenstein HJ., López OL, Morow L, Saxton J, Tárraga L. 

MMP-2/MMP-9 plasma level and brain expression in CAA-associated hemorrhagic stroke 
Brain Pathol. 2012 Mar;22(2):133-41.  I.F.: 4.99   doi: 10.1111/j.1750-3639.2011.00512.x. Epub 2011 Sep 15.
Hernandez-Guillamon M, Martinez-Saez E, Delgado P, Domingues-Montanari S, Boada C, Penalba A, Boada M, Pagola J, Maisterra O, Rodriguez-Luna D, Molina CA, Rovira A, Alvarez-Sabin J, Ortega-Aznar A, Montaner J. 

Plasma β-amyloid levels in Cerebral Amyloid Angiopathy-associated hemorrhagic stroke 
Neurodegener Dis. 2012;10(1-4):320-3.  I.F.: 3.06   doi: 10.1159/000333811. Epub 2012 Jan 17.
Hernández-Guillamon M, Delgado O, Penalba A, Rodríguez-Luna D, Molina CA, Rovira A, Álvarez-Sabin J, Boada M, Montanter

Normative data of a brief Neuropsychological Battery for Spanish Individuals Older than 49 
J Clin Exp Neuropsychol. 2012;34(2):209-19.  I.F.: 1.80   doi: 10.1080/13803395.2011.630652. Epub 2011 Dec 13.
Alegret M, Espinosa A, Vinyes-Junqué G, Valero S, Hernández I, Tárraga L, Becker JT, Boada M.

Total Listing 19

118,89

Tsallis entropy approach to radiotherapy treatments 

Physica A: Statistical Mechanics and its Applications, Volume 392, Issue 9, 1 May 2013, Pages 2007-2015, ISSN 0378-4371, I.F.: 1,676

Rodriguez-Perez D, Sotolongo-Costa O, Antoranz JC.


ATP5H/KCTD2 locus is associated with Alzheimer's disease risk

Mol Psychiatry. 2014 Jun;  I.F.: 14,9  doi:19(6):682-7.

Boada M, Antúnez C, Ramírez-Lorca R, Destefano AL, González-Pérez A, Gayán J, López-Arrieta J, Ikram MA, Hernández I, Marín J, Galán JJ, Bis JC, Mauleón A, Rosende-Roca M, Moreno-Rey C, Gudnasson V, Morón FJ, Velasco J, Carrasco JM, Alegret M, Espinosa A, Vinyes G, Lafuente A, Vargas L, Fitzpatrick AL; for the Alzheimer’s Disease Neuroimaging Initiative, Launer LJ, Sáez ME, Vázquez E, Becker JT, López OL, Serrano-Ríos M, Tárraga L, van Duijn CM, Real LM, Seshadri S, Ruiz A. 


Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation
J Neurol Neurosurg Psychiatry. 2014 Jun;  I.F.: 4,92   doi:85(6):684-91
Suárez-Calvet M, Dols-Icardo O, Lladó A, Sánchez-Valle R, Hernández I, Amer G, Antón-Aguirre S, Alcolea D, Fortea J, Ferrer I, van der Zee J, Dillen L, Van Broeckhoven C, Molinuevo JL, Blesa R, Clarimón J, Lleó A.

Design of a comprehensive Alzheimer's disease clinic and research center in Spain to meet critical patient and family needs

Alzheimers Dement. 2014 May;  I.F.:4,48  doi:10(3):409-15.

Valero S, Alegret M, Ruiz A, Lopez OL, Becker JT; Fundació ACE Alzheimer Research Center and Memory Clinic. 


Characterization of the repeat expansion size in C9orf72 in amyotrophic lateral sclerosis and frontotemporal dementia 

Hum Mol Genet. 2014 Feb   I.F.: 7,69   doi:1;23(3):749-54.

Dols-Icardo O, García-Redondo A, Rojas-García R, Sánchez-Valle R, Noguera A, Gómez-Tortosa E, Pastor P, Hernández I, Esteban-Pérez J, Suárez-Calvet M, Antón-Aguirre S, Amer G, Ortega-Cubero S, Blesa R, Fortea J, Alcolea D, Capdevila A, Antonell A, Lladó A, Muñoz-Blanco JL, Mora JS, Galán-Dávila L, Rodríguez De Rivera FJ, Lleó A, Clarimón J.


Assessing the Role of the Trem2 P.R47h Variant as a Risk Factor for Alzheimer's Disease and Frontotemporal Dementia

Neurobiol Aging. 2014 Feb;    I.F.: 4.85    doi:35(2):444.e1-4.

Ruiz A, Dols-Icardo O, Bullido MJ, Pastor P, Rodríguez-Rodríguez E, López de Munain A, de Pancorbo MM, Pérez-Tur J, Alvarez V, Antonell A, López-Arrieta J, Hernández I, Tárraga L, Boada M, Lleó A, Blesa R, Frank-García A, Sastre I, Razquin C, Ortega-Cubero S, Lorenzo E, Sánchez-Juan P, Combarros O, Moreno F, Gorostidi A, Elcoroaristizabal X, Baquero M, Coto E, Sánchez-Valle R, Clarimón J; dementia genetic Spanish consortium (DEGESCO). 


Identification of Misdiagnosed Fronto-Temporal Dementia using APOE Genotype and Phenotype-Genotype Correlation Analyses 

Curr Alzheimer Res. 2014 Feb; I.F.: 3,68  doi:11(2):182-91

Hernández I, Mauleón A, Rosende-Roca M, Alegret M, Vinyes G, Espinosa A, Sotolongo-Grau O, Becker JT, Valero S, Tárraga L, López OL, Ruiz A, Boada M. 


Genetic analysis of candidate SNPs for metabolic syndrome in obstructive sleep apnea (OSA) 

Gene. 2013 May 25;  I.F.: 2.2  doi:521(1):150-4. 

Grilo A, Ruiz-Granados ES, Moreno-Rey C, Rivera JM, Ruiz A, Real LM, Sáez ME.


Cut-off Scores of a brief Neuropsychological Battery (NBACE) for Spanish Individual adults older than 44 years old

PLoS One. 2013 Oct   I.F.: 3.73   doi:16;8(10):e76436.

Alegret M, Espinosa A, Valero S, Vinyes-Junqué G, Ruiz A, Hernández I, Rosende-Roca M, Mauleón A, Becker JT, Tárraga L, Boada M.


Meta-analysis of 74,538 individuals identifies 11 new susceptibility loci for Alzheimer’s disease

Nat Genet. 2013 Dec;  I.F.: 35.209   doi:45(12):1452-8.

Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, Jun G, Destefano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Gerrish A, Schmidt H, Kunkle B, Dunstan ML, Ruiz A, Bihoreau MT, Choi SH, Reitz C, Pasquier F, Hollingworth P, Ramirez A, Hanon O, Fitzpatrick AL, Buxbaum JD, Campion D, Crane PK, Baldwin C, Becker T, Gudnason V, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Morón FJ, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MJ, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuinness B, Larson EB, Green R, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez-Garcia F, Fox NC, Hardy J, Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Mancuso M, Matthews F; European Alzheimer's Disease Initiative (EADI); Genetic and Environmental Risk in Alzheimer's Disease (GERAD); Alzheimer's Disease Genetic Consortium (ADGC); Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE), Moebus S, Mecocci P, Del Zompo M, Maier W, Hampel H, Pilotto A, Bullido M, Panza F, Caffarra P, Nacmias B, Gilbert JR, Mayhaus M, Lannfelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH Jr, Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltunen M, Martin ER, Schmidt R, Rujescu D, Wang LS, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nöthen MM, Graff C, Psaty BM, Jones L, Haines JL, Holmans PA, Lathrop M, Pericak-Vance MA, Launer LJ, Farrer LA, van Duijn CM, Van Broeckhoven C, Moskvina V, Seshadri S, Williams J, Schellenberg GD, Amouyel P. 

Blood amyloid beta levels in healthy, Mild Cognitive Impairment and Alzheimer's disease individuals: replication of diastolic blood pressure correlations and analysis of critical covariates
PLoS One. 2013 Nov  I.F.: 3.73   doi:27;8(11):e81334.
Agustín Ruiz, Pedro Pesini, Ana Espinosa, Virginia Pérez-Grijalba, Sergi Valero, Oscar Sotolongo-Grau, Montserrat Alegret, Inmaculada Monleón, Asunción Lafuente, Mar Buendía, Marta Ibarria, Susana Ruiz; Isabel Hernández; Itziar San José, Lluís Tárraga, Mercè Boada, Manuel Sarasa.

Rare variants in Calcium homeostasis modulator 1 (CALHM1) gene found in early onset Alzheimer's disease patients alter calcium homeostasis
PLoS One. 2013 Sep   I.F.: 3.73   doi:17;8(9):e74203. 
Rubio-Moscardo F, Setó-Salvia N, Pera M, Bosch-Morató M, Plata C, Belbin O, Gené G, Dols-Icardo O, Ingelsson M, Helisalmi S, Soininen H, Hiltunen M, Giedraitis V, Lannfelt L, Frank A, Bullido MJ, Combarros O, Sánchez-Juan P, Boada M, Tárraga L, Pastor P, Pérez-Tur J, Baquero M, Molinuevo JL, Sánchez-Valle R, Fuentes-Prior P, Fortea J, Blesa R, Muñoz FJ, Lleó A, Valverde MA, Clarimón J. 

Single-Domain Amnestic Mild Cognitive Impairment Identified by Cluster Analysis Predicts Alzheimer's Disease in the European Prospective DESCRIPA Study
Dement Geriatr Cogn Disord 2013;  I.F.: 2.79   doi:10.1159/000348354. Epub 2013 May 3.
Damian M, Hausner L, Jekel K, Richter M, Froelich L, Almkvist O, Boada M, Bullock R, De Deyn PP, Frisoni GB, Hampel H, Jones RW, Kehoe P, Lenoir H, Minthon L, Olde Rikkert MGM, Rodriguez G, Scheltens P, Soininen H, Spiru L, Touchon J, Tsolaki M, Vellas B, Verhey FRJ, Winblad B, Wahlund LO, Wilcock G, Visser PJ.

A longitudinal follow-up of 550 Mild Cognitive Impairment patients: evidence for large conversión to dementia rates and detection of major risk factors involved
J Alzheimers Dis. 2013 Jan 1;  I.F.: 4.17   doi:34(3):769-80. PDF ResearchGate
Espinosa A, Alegret M, Valero S, Vinyes-Junqué G, Hernández I, Mauleón A, Rosende-Roca M, Ruiz A, López O, Tárraga L, Boada M. 

Several Direct and Calculated Biomarkers from the Amyloid-β Pool in Blood are Associated with an Increased Likelihood of Suffering from Mild Cognitive Impairment 
J Alzheimers Dis. 2013 Jan  I.F.: 4.17  doi:1;36(1):211-9
Pérez-Grijalba V, Pesini P, Monleón I, Boada M, Tárraga L, Ruiz-Laza A, Martínez-Lage P, San-José I, Sarasa M. 

Transdermal is better than oral: observational research of the satisfaction of caregivers of patients with Alzheimer’s disease treated with rivastigmine
Dement Geriatr Cogn Disord. 2013;  I.F.:  2.79  doi:35(1-2):23-33
Boada M, Arranz FJ. 

Genetic Study of Neurexin and Neuroligin Genes in Alzheimer's Disease

J Alzheimers Dis. 2013;  I.F.: 4.18   doi:35(2):403-12

Martínez-Mir A, González-Pérez A, Gayan J, Antúnez C, Marin J, Boada M, López-Arrieta, JK, Fernández E, Ruiz A, Gómez Scholl F, Real LM. 


Utilidad de la Lista de Palabras de la Wechsler Memory Scale-III para valorar la memoria episódica verbal en la evaluación forense
Rev Esp Med Legal. 2013; doi:39:78-81.
Alegret M, Espinosa A, Ibarria M, Cañabate P, Boada M.

Atenció a persones amb demència i la seva família
Revista de Treball Social. Col·legi Oficial de Treball Social de Catalunya, abril 2013, nº 198, pàgines 92-97. ISSN 0212-7210.
Cañabate P; Moreno M; Cerdán M. 

Total Listing 24

127,5
Treatment of Alzheimer disease using combination therapy with plasma exchange and haemapheresis with albumin and intravenous immunoglobulin: Rationale and treatment approach of the AMBAR (Alzheimer Management By Albumin Replacement) study
Neurologia. 2016 Sep;  I.F.: 1,35   doi:31(7):473-81 9.
Boada M, Ramos-Fernández E, Guivernau B, Muñoz FJ, Costa M, Ortiz AM, Jorquera JI, Núñez L, Torres M, Páez A. 

Convergent genetic and expression data implicate immunity in Alzheimer's disease

Alzheimers Dement. 2015 Jun;  I.F.: 17.47  doi:11(6):658-71.

International Genomics of Alzheimer's Disease Consortium IGAP.


Association of TMEM106B rs1990622 Marker and Frontotemporal Dementia: Evidence for a Recessive Effect and Meta-Analysis

J Alzheimers Dis. 2015;  I.F: 4.51    doi:43(1):325-34.

Hernández I, Rosende-Roca M, Alegret M, Mauleón A, Espinosa A, Vargas L, Sotolongo-Grau O, Tárraga L, Boada M, Ruiz A. 


A Phase II Trial of Tideglusib in Alzheimer's Disease
J Alzheimers Dis. 2015 Jan   I.F.: 3,61    doi:1;45(1):75-88
Lovestone S, Boada M, Dubois B, Hüll M, Rinne JO, Huppertz HJ, Calero M, Andrés MV, Gómez-Carrillo B, León T, Del Ser T. 

Aβ1-17 is a Major Amyloid-β Fragment Isoform in Cerebrospinal Fluid and Blood with Possible Diagnostic Value in Alzheimer's Disease
J Alzheimers Dis. Jan 2015   I.F.: 3,61   dio: 1;43(1):47-56
Pérez-Grijalba V, Pesini P, Allué JA, Sarasa L, Montañés M, Lacosta AM, Casabona D, San-José I, Boada M, Tárraga L, Ruiz A, Sarasa M. 

A colorectal cancer susceptibility new variant at 4q26 in the Spanish population identified by genome-wide association analysis
PLoS One. 2014 Jun  I.F: 3,73   doi:30;9(6):e101178.
Morón FJ, Velasco J, Marginet-Flinch R, Musulén E, Carrasco JM, Moreno-Rey C, Vázquez E, Chaves-Conde M, Moreno-Nogueira JA, Hidalgo-Pascual M, Ferrero-Herrero E, Castellví-Bel S, Castells A, Fernandez-Rozadilla C, Ruiz-Ponte C, Carracedo A, González B, Alonso S, Perucho M. 

Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes

Neurobiol Aging. 2014 Nov;  I.F.:4,85  doi:35(11):2657.e13-9.

Thelen M, Razquin C, Hernández I, Gorostidi A, Sánchez-Valle R, Ortega-Cubero S, Wolfsgruber S, Drichel D, Fliessbach K, Duenkel T, Damian M, Heilmann S, Slotosch A, Lennarz M, Seijo-Martínez M, Rene R, Kornhuber J, Peters O, Luckhaus C, Jahn H, Hüll M, Rüther E, Wiltfang J, Lorenzo E, Gascon J, Lleó A, Lladó A, Campdelacreu J, Moreno F, Ahmadzadehfar H; Dementia Genetics Spanish Consortium (DEGESCO), Fortea J, Indakoetxea B, Heneka MT, Wetter A, Pastor MA, Riverol M, Becker T, Frölich L, Tárraga L, Boada M, Wagner M, Jessen F, Maier W, Clarimón J, López de Munain A, Ruiz A, Pastor P, Ramirez A. 


Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders

Mov Disord. 2014 Jul;29(8):1010-8. I.F.: 5,63  doi: 10.1002/mds.25776. Epub 2014 Jan 2.

Gelpi E, Navarro-Otano J, Tolosa E, Gaig C, Compta Y, Rey MJ, Martí MJ, Hernández I, Valldeoriola F, Reñé R, Ribalta T. 


Cognitive, genetic, and brain perfusion factors associated with four year incidence of Alzheimer's disease from mild cognitive impairment 
J Alzheimers Dis. 2014;  I.F.: 3,61  doi:41(3):739-48.
Alegret M, Cuberas-Borrós G, Espinosa A, Valero S, Hernández I, Ruíz A, Becker JT, Rosende-Roca M, Mauleón A, Sotolongo O, Castell-Conesa J, Roca I, Tárraga L, Boada M

Effects of Gingko biloba supplementation in Alzheimer's disease patients receiving cholinesterase inhibitors: data from the ICTUS study
Phytomedicine. 2014 May I.F.: 2,88  doi:15;21(6):888-92.
Canevelli M, Adali N, Kelaiditi E, Cantet C, Ousset PJ, Cesari M; ICTUS/DSA Group.

A 2-year prospective cohort study of antidementia drug non-persistency in mild-to-moderate Alzheimer's disease in Europe : predictors of discontinuation and switch in the ICTUS study
ICTUS Group. CNS Drugs. 2014 Feb;  I.F.: 4,38  doi:28(2):157-70.
Gardette V, Lapeyre-Mestre M, Piau A, Gallini A, Cantet C, Montastruc JL, Vellas B, Andrieu S;

A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy

Mov Disord. 2014 Apr;29(4):470-8.  I.F.: 5,63   doi: 10.1002/mds.25824

Tolosa E, Litvan I, Höglinger GU, Burn D, Lees A, Andrés MV, Gómez-Carrillo B, León T, Del Ser T; TAUROS Investigators. 


Frontotemporal dementia and its subtypes: a genome-wide association study
Lancet Neurol 2014; I.F.: 23,92  doi:13: 686–99
Ferrari R, Hernandez DG, Nalls MA, Rohrer JD, Ramasamy A, Kwok JB, Dobson-Stone C, Brooks WS, Schofield PR, Halliday GM, Hodges JR, Piguet O, Bartley L, Thompson E, Haan E, Hernández I, Ruiz A, Boada M, Borroni B, Padovani A, Cruchaga C, Cairns NJ, Benussi L, Binetti G, Ghidoni R, Forloni G, Galimberti D, Fenoglio C, Serpente M, Scarpini E, Clarimón J, Lleó A, Blesa R, Waldö ML, Nilsson K, Nilsson C, Mackenzie IR, Hsiung GY, Mann DM, Grafman J, Morris CM, Attems J, Griffiths TD, McKeith IG, Thomas AJ, Pietrini P, Huey ED, Wassermann EM, Baborie A, Jaros E, Tierney MC, Pastor P, Razquin C, Ortega-Cubero S, Alonso E, Perneczky R, Diehl-Schmid J, Alexopoulos P, Kurz A, Rainero I, Rubino E, Pinessi L, Rogaeva E, St George-Hyslop P, Rossi G, Tagliavini F, Giaccone G, Rowe JB, Schlachetzki JC, Uphill J, Collinge J, Mead S, Danek A, Van Deerlin VM, Grossman M, Trojanowski JQ, van der Zee J, Deschamps W, Van Langenhove T, Cruts M, Van Broeckhoven C, Cappa SF, Le Ber I, Hannequin D, Golfier V, Vercelletto M, Brice A, Nacmias B, Sorbi S, Bagnoli S, Piaceri I, Nielsen JE, Hjermind LE, Riemenschneider M, Mayhaus M, Ibach B, Gasparoni G, Pichler S, Gu W, Rossor MN, Fox NC, Warren JD, Spillantini MG, Morris HR, Rizzu P, Heutink P, Snowden JS, Rollinson S, Richardson A, Gerhard A, Bruni AC, Maletta R, Frangipane F, Cupidi C, Bernardi L, Anfossi M, Gallo M, Conidi ME, Smirne N, Rademakers R, Baker M, Dickson DW, Graff-Radford NR, Petersen RC, Knopman D, Josephs KA, Boeve BF, Parisi JE, Seeley WW, Miller BL, Karydas AM, Rosen H, van Swieten JC, Dopper EG, Seelaar H, Pijnenburg YA, Scheltens P, Logroscino G, Capozzo R, Novelli V, Puca AA, Franceschi M, Postiglione A, Milan G, Sorrentino P, Kristiansen M, Chiang HH, Graff C, Pasquier F, Rollin A, Deramecourt V, Lebert F, Kapogiannis D, Ferrucci L, Pickering-Brown S, Singleton AB, Hardy J, Momeni P

Gene-wide analysis detects two new susceptibility genes for Alzheimer’s disease

PLoS One. 2014 Jun I.F.:  3,73  doi:12;9(6):e94661.

Escott-Price V, Bellenguez C, Wang LS, Choi SH, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert JC, Ibrahim-Verbaas CA, Naj AC, Sims R, Jun G, Bis JC, Beecham GW, Grenier-Boley B, Russo G1, Thornton-Wells TA, Denning N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Schmidt H, Kunkle B, Dunstan ML, Vronskaya M; United Kingdom Brain Expression Consortium, Johnson AD, Ruiz A, Bihoreau MT, Reitz C, Pasquier F, Hollingworth P, Hanon O, Fitzpatrick AL, Buxbaum JD, Campion D, Crane PK, Baldwin C, Becker T, Gudnason V, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Hernández I, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MJ, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuinness B, Larson EB, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, George-Hyslop PS, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Garcia FS, Fox NC, Hardy J, Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Scarpini E, Bonuccelli U, Mancuso M, Siciliano G, Moebus S, Mecocci P, Zompo MD, Maier W, Hampel H, Pilotto A, Frank-García A, Panza F, Solfrizzi V, Caffarra P, Nacmias B, Perry W, Mayhaus M, Lannfelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH Jr, Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltunen M, Martin ER, Schmidt R, Rujescu D, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nöthen MM, Graff C, Psaty BM, Haines JL, Lathrop M, Pericak-Vance MA, Launer LJ, Van Broeckhoven C, Farrer LA, van Duijn CM, Ramirez A, Seshadri S, Schellenberg GD, Amouyel P, Williams J.


Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial 

Mov Disord. 2014 Apr;  I.F.: 5,63  doi:29(4):479-87.  Boada M, Lafuente A cited as collaborators

Höglinger GU1, Huppertz HJ, Wagenpfeil S, Andrés MV, Belloch V, León T, Del Ser T; TAUROS MRI Investigators. 


Methylglyoxal Produced by Amyloid-β Peptide-Induced Nitrotyrosination of Triosephosphate Isomerase Triggers Neuronal Death in Alzheimer's Disease
J Alzheimers Dis. 2014 Jan   I.F. 3,61   doi:1;41(1):273-88.
Tajes M, Eraso-Pichot A, Rubio-Moscardó F, Guivernau B, Ramos-Fernández E, Bosch-Morató M, Guix FX, Clarimón J, Miscione GP, Boada M, Gil-Gómez G, Suzuki T, Molina H, Villà-Freixa J, Vicente R, Muñoz FJ. 

Approaching allelic probabilities and Genome-Wide Association Studies from beta distributions

arXiv:1402.6151 [q-bio.GN] 25 feb 2014

J. Santiago García-Cremades, Ángel del Río, José A. García, Javier Gayán, Antonio González-Pérez, Agustín Ruiz, Oscar Sotolongo-Grau, Manuel Ruiz-Marín. 


Posttranslational Nitro-Glycative Modifications of Albumin in Alzheimer's Disease: Implications in Cytotoxicity and Amyloid-β Peptide Aggregation
J Alzheimers Dis. 2014 Jan   I.F.:  3,61   doi:1;40(3):643-57.
Ramos-Fernández E, Tajes M, Palomer E, Ill-Raga G, Bosch-Morató M, Guivernau B, Román-Dégano I, Eraso-Pichot A, Alcolea D, Fortea J, Nuñez L, Paez A, Alameda F, Fernández-Busquets X, Lleó A, Elosúa R, Boada M, Valverde MA, Muñoz FJ. 

Association between cell-bound blood amyloid-β(1–40) levels and hippocampus volume
Alzheimers Res Ther. 2014 Oct 20;6(5-8):56.  I.F.: 3,50  doi: 10.1186/s13195-014-0056-3. eCollection 2014.
Sotolongo-Grau O, Pesini P, Valero S, Lafuente A, Buendia M, Pérez-Grijalba V, José IS, Ibarria M, Tejero MA, Giménez J, Hernández I, Tárraga L, Ruiz A, Boada M, Sarasa M.

Prevention of Alzheimer’s Disease: A Global Challenge for Next Generation Neuroscientists
J Alzheimers Dis. 2014;42 Suppl 4:S515-23.  I.F.: 3,61   doi: 10.3233/JAD-141479.
Rodríguez-Gómez O, Palacio-Lacambra ME, Palasí A, Ruiz-Laza A, Boada-Rovira M.

Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration
Acta Neuropathol. 2014 Sep;128(3):397-410.  I.F.: 9,73   doi: 10.1007/s00401-014-1298-7. Epub 2014 Jun 5.
Van der Zee J, Van Langenhove T, Kovacs GG, Dillen L, Deschamps W, Engelborghs S, Matěj R, Vandenbulcke M, Sieben A, Dermaut B, Smets K, Van Damme P, Merlin C, Laureys A, Van Den Broeck M, Mattheijssens M, Peeters K, Benussi L, Binetti G, Ghidoni R, Borroni B, Padovani A, Archetti S, Pastor P, Razquin C, Ortega-Cubero S, Hernández I, Boada M, Ruiz A, de Mendonça A, Miltenberger-Miltényi G, do Couto FS, Sorbi S, Nacmias B, Bagnoli S, Graff C, Chiang HH, Thonberg H, Perneczky R, Diehl-Schmid J, Alexopoulos P, Frisoni GB, Bonvicini C, Synofzik M, Maetzler W, Vom Hagen JM, Schöls L, Haack TB, Strom TM, Prokisch H, Dols-Icardo O, Clarimón J, Lleó A, Santana I, Almeida MR, Santiago B, Heneka MT, Jessen F, Ramirez A, Sanchez-Valle R, Llado A, Gelpi E, Sarafov S, Tournev I, Jordanova A, Parobkova E, Fabrizi GM, Testi S, Salmon E, Ströbel T, Santens P, Robberecht W, De Jonghe P, Martin JJ, Cras P, Vandenberghe R, De Deyn PP, Cruts M, Sleegers K, Van Broeckhoven C.

Utilidad del subtest Semejanzas de la Escala de Inteligencia de Wechsler para Adultos-III y su relación con la conciencia de déficit en la evaluación forense del deterioro cognitivo
Revista Española de Medicina Legal.  I.F.: 0,22  doi:10.1016/j.reml.2014.03.001
Espinosa A, Alegret A, Ibarria M, Ortega G, Cañabate P, Boada M.

Follow up of loci from the International Genomics of Alzheimer’s Disease Project identifies TRIP4 as a novel susceptibility gene
Transl Psychiatry. 2014 Feb 4;4:e358.  I.F.: 4,36   doi: 10.1038/tp.2014.2.
Ruiz A, Heilmann S, Becker T, Hernández I, Wagner H, Thelen M, Mauleón A, Rosende-Roca M, Bellenguez C, Bis JC, Harold D, Gerrish A, Sims R, Sotolongo-Grau O, Espinosa A, Alegret M, Arrieta JL, Lacour A, Leber M, Becker J, Lafuente A, Ruiz S, Vargas L, Rodríguez O, Ortega G, Dominguez MA; IGAP, Mayeux R, Haines JL, Pericak-Vance MA, Farrer LA, Schellenberg GD, Chouraki V, Launer LJ, van Duijn C, Seshadri S, Antúnez C, Breteler MM, Serrano-Ríos M, Jessen F, Tárraga L, Nöthen MM, Maier W, Boada M, Ramírez A.

Valoración de las funciones visuoperceptivas y visuoespaciales en la práctica forense 
Rev Esp Med Legal. 2014;40:83-5.  I.F.: 0,22
Ortega G, Alegret M, Espinosa A, Ibarria M, Cañabate P, Boada M.

Total Listing 15

135.03
MAPT H1 Haplotype is Associated with Late-Onset Alzheimer's Disease Risk in APOEɛ4 Noncarriers: Results from the Dementia Genetics Spanish Consortium
J Alzheimers Dis. 2015 Sep 29; I.F.: 4.15  doi:49(2):343-52.
Pastor P, Moreno F, Clarimón J, Ruiz A, Combarros O, Calero M, López de Munain A, Bullido MJ, de Pancorbo MM, Carro E, Antonell A, Coto E, Ortega-Cubero S, Hernandez I, Tárraga L, Boada M, Lleó A, Dols-Icardo O, Kulisevsky J, Vázquez-Higuera JL, Infante J, Rábano A, Fernández-Blázquez MÁ, Valentí M, Indakoetxea B, Barandiarán M, Gorostidi A, Frank-García A, Sastre I, Lorenzo E, Pastor MA, Elcoroaristizabal X, Lennarz M, Maier W, Rámirez A, Serrano-Ríos M, Lee SE, Sánchez-Juan P

Diagostic accuracy of FTD behavioural frontotemporal dementia criteria in a clinicopathological cohort

Neuropathol Appl Neurobiol. 2015 Dec;   I.F.: 3.93   doi:41(7):882-92.

Balasa M, Gelpi E, Martín I, Antonell A, Rey M, Grau-Rivera O, Molinuevo J, Sánchez-Valle R, Lladó A; Catalan collaborative Study Group for FTLD. 


Analysis of the CHCHD10 gene in patients with frontotemporal dementia and amyotrophic lateral sclerosis from Spain

J. Brain. 2015 Dec;  I.F.: 9.19  doi:138(Pt 12):e400.

Dols-Icardo, O , Nebot I , Gorostidi A, Ortega-Cubero S, Hernández I, Rojas-García R, García-Redondo A, Povedano M, Lladó A, Álvarez V, Sánchez-Juan P, Pardo J , Jericó I, Vázquez-Costa J, Sevilla T, Cardona F, Indakoechea B, Moreno F, Fernández-Torrón R, Muñoz-Llahuna L, Moreno-Grau S, Rosende-Roca M, Vela A, Muñoz-Blanco JL, Combarros O, Coto E, Alcolea D, Fortea J, Lleó A, Sánchez-Valle R, Esteban-Pérez J, Ruiz A, Pastor P, López De Munain A, Pérez-Tur J, Clarimón J


Subjective Cognitive Decline in Older Adults: An Overview of Self-Report Measures Used Across 19 International Research Studies
J Alzheimers Dis. 2015 Sep    I.F.: 4.15    doi:24;48 Suppl 1:S63-86.
Rabin LA, Smart CM, Crane PK, Amariglio RE, Berman LM, Boada M, Buckley RF, Chételat G, Dubois B, Ellis KA, Gifford KA, Jefferson AL, Jessen F, Katz MJ, Lipton RB, Luck T, Maruff P, Mielke MM, Molinuevo JL, Naeem F, Perrotin A, Petersen RC, Rami L, Reisberg B, Rentz D, Riedel-Heller SG, Risacher SL, Rodriguez O, Sachdev PS, Saykin AJ, Slavin MJ, Snitz BE, Sperling RA, Tandetnik C, van der Flier WM, Wagner M, Wolfsgruber S, Sikkes SA. 

Validation of the Spanish Version of the Face Name Associative Memory Exam (S-FNAME) in Cognitively Normal Older Individuals

Arch Clin Neuropsychol. 2015 Nov;   I.F.: 1.99    doi:30(7):712-20. 

Alegret M, Valero S, Ortega G, Espinosa A, Sanabria A, Hernández I, Rodríguez O, Rosende-Roca M, Mauleón A, Vargas L, Martín E, Ruíz A, Tárraga L, Amariglio RE, Rentz DM, Boada M.


Influence of Sampling and Recruitment Methods in Studies of Subjective Cognitive Decline

J Alzheimers Dis. 2015 Sep I.F.: 4.15   doi:24;48 Suppl 1:S99-S107.

Rodríguez-Gómez O, Abdelnour C, Jessen F, Valero 3, Boada M.

Genetic variability in SQSTM1 and risk of early-onset Alzheimer dementia: a European early-onset dementia consortium study

Neurobiol Aging. 2015 May;  I.F.: 5.01    doi:36(5):2005.e15-22.

Cuyvers E, van der Zee J, Bettens K, Engelborghs S, Vandenbulcke M, Robberecht C, Dillen L, Merlin C, Geerts N, Graff C, Thonberg H, Chiang HH, Pastor P, Ortega-Cubero S, Pastor MA, Diehl-Schmid J, Alexopoulos P, Benussi L, Ghidoni R, Binetti G, Nacmias B, Sorbi S, Sanchez-Valle R, Lladó A, Gelpi E, Almeida MR, Santana I, Clarimon J, Lleó A, Fortea J, de Mendonça A, Martins M, Borroni B, Padovani A, Matěj R, Rohan Z, Ruiz A, Frisoni GB, Fabrizi GM, Vandenberghe R, De Deyn PP, Van Broeckhoven C, Sleegers K; BELNEU Consortium and of the EU EOD Consortium. 


Differentiated clinical presentation of early and late-onset Alzheimer's disease: is 65 years of age providing a reliable threshold?
J Neurol. 2015 May;  I.F.: 3,37     doi:262(5):1238-46
Palasí A, Gutiérrez-Iglesias B, Alegret M, Pujadas F, Olabarrieta M, Liébana D, Quintana M, Álvarez-Sabín J, Boada M. 

PLD3 in non-familial Alzheimer's disease

Nature. 2015 Apr   F.I.: 41.45   doi:2;520(7545):E3-5.

Heilmann S, Drichel D, Clarimon J, Fernández V, Lacour A, Wagner H, Thelen M, Hernández I, Fortea J, Alegret M, Blesa R, Mauleón A, Roca MR, Kornhuber J, Peters O, Heun R, Frölich L, Hüll M, Heneka MT, Rüther E, Riedel-Heller S, Scherer M, Wiltfang J, Jessen F, Becker T, Tárraga L, Boada M, Maier W, Lleó A, Ruiz A, Nöthen MM, Ramirez A. 


Assessing the Role of TUBA4A Gene in Frontotemporal Degeneration
Neurobiol Aging. 2016 Feb;38:215.e13-215.e14  I.F.: 5,01  doi: 10.1016/j.neurobiolaging.2015.10.030. Epub 2015 Nov 5.
Dols-Icardo O, Iborra O, Valdivia J, Pastor P, Ruiz A, López de Munain A, Sánchez-Valle R, Álvarez V, Sánchez-Juan P, Lleó A, Fortea J, Blesa R, Cardona F, Baquero M, Alonso MD, Ortega-Cubero S, Pastor MA, Razquin C, Boada M, Hernández I, Gorostidi A, Moreno F, Zulaica M, Lladó A, Coto E, Combarros O, Pérez-Tur J, Clarimón J on behalf of The Dementia Genetics Spanish Consortium (DEGESCO). 

A Truncating Mutation in Alzheimer’s Disease Inactivates Neuroligin-1 Synaptic Function
Neurobiol Aging. 2015 Dec;36(12):3171-3175.  I.F.: 5,01   doi: 10.1016/j.neurobiolaging.2015.09.004. Epub 2015 Sep 10.
Tristán-Clavijo, E, Camacho-Garcia, R J, Robles-Lanuza, E, Ruiz, A, van der Zee, J, Van Broeckhoven, C, Hernández I, Martínez-Mir A, Scholl, F G (2015)
 
A novel Alzheimer disease locus located near the gene encoding tau protein
Mol Psychiatry. 2016 Jan;21(1):108-17.  I.F.: 14.50   doi: 10.1038/mp.2015.23. Epub 2015 Mar 17.
Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS, Bis JC, Bellengez C, Harold D, Lunetta KL, Destefano AL, Grenier-Boley B, Sims R, Beecham GW, Smith AV, Chouraki V, Hamilton-Nelson KL7, Ikram MA, Fievet N, Denning N, Martin ER, Schmidt H, Kamatani Y, Dunstan ML, Valladares O, Laza AR, Zelenika D, Ramirez A, Foroud TM, Choi SH, Boland A, Becker T, Kukull WA, van der Lee SJ, Pasquier F, Cruchaga C, Beekly D, Fitzpatrick AL, Hanon O, Gill M, Barber R, Gudnason V, Campion D, Love S, Bennett DA, Amin N, Berr C, Tsolaki M, Buxbaum JD, Lopez OL, Deramecourt V, Fox NC, Cantwell LB, Tárraga L, Dufouil C, Hardy J, Crane PK, Eiriksdottir G, Hannequin D, Clarke R, Evans D, Mosley TH Jr, Letenneur L, Brayne C, Maier W, De Jager P, Emilsson V, Dartigues JF, Hampel H, Kamboh MI, de Bruijn RF, Tzourio C, Pastor P, Larson EB, Rotter JI, O'Donovan MC, Montine TJ, Nalls MA, Mead S, Reiman EM, Jonsson PV, Holmes C, St George-Hyslop PH, Boada M, Passmore P, Wendland JR, Schmidt R, Morgan K, Winslow AR, Powell JF, Carasquillo M, Younkin SG, Jakobsdóttir J, Kauwe JS, Wilhelmsen KC, Rujescu D, Nöthen MM, Hofman A, Jones L; IGAP Consortium, Haines JL, Psaty BM, Van Broeckhoven C, Holmans P, Launer LJ, Mayeux R, Lathrop M, Goate AM, Escott-Price V, Seshadri S, Pericak-Vance MA, Amouyel P, Williams J, van Duijn CM, Schellenberg GD, Farrer LA.
 
Concordance between Subjective and Objective Memory Impairment in Volunteer Subjects
J Alzheimers Dis. 2015;48(4):1109-17.  I.F.: 4,15  doi: 10.3233/JAD-150594.
Alegret M, Rodríguez O, Espinosa A, Ortega G, Sanabria A, Valero S, Hernández I, Rosende-Roca M, Vargas L, Abdelnour C, Mauleón A, Gailhajanet A, Martín E, Tárraga L, Rentz DM, Amariglio RE, Ruíz A, Boada M. 

Evaluation of Candidate Genes Related to Neuronal Apoptosis in Late-Onset Alzheimer's Disease 
J Alzheimers Dis. 2015;  I.F.: 4.15  doi:45(2):621-9.
Moreno-Grau S, Barneda B, Carriba P, Marín J, Sotolongo-Grau O, Hernández I, Rosende-Roca M, Mauleón A, Vargas L, Espinosa A, Alegret M, Rodriguez O, Ortega G, Fernández MV, López-Arrieta J, Tárraga L, Boada M, Antúnez C, López J, Ruiz A, Comella JX J 

Retirement age and the age of onset of Alzheimer's disease: results from the ICTUS study 
PLoS One. 2015 Feb 25;10(2):e0115056. F.I. 3.23  doi: 10.1371/journal.pone.0115056.  eCollection 2015.
Grotz C, Letenneur L, Bonsang E, Amieva H, Meillon C, Quertemont E, Salmon E, Adam S; ICTUS/DSA group.

Total Listing 13

79.26

Shared genetic contribution to ischemic stroke and Alzheimer's disease

Ann Neurol. 2016 May; I.F.: 9.98  doi: 79(5): 739–747. 

Matthew Traylor, Poneh Adib‐Samii, Denise Harold, the Alzheimer's Disease Neuroimaging Initiative, The International Stroke Genetics Consortium (ISGC), UK Young Lacunar Stroke DNA resource, Martin Dichgans, Julie Williams, Cathryn M. Lewis, Hugh S. Markus, and and the METASTROKE and International Genomics of Alzheimer's Project (IGAP) investigators.


TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis 
Hum Mutat. 2017 Mar; I.F.: 5.09  doi: 38(3):297-309   
van der Zee J, Gijselinck I, Van Mossevelde S, Perrone F, Dillen L, Heeman B, Bäumer V, Engelborghs S, De Bleecker J, Baets J, Gelpi E, Rojas-García R, Clarimón J, Lleó A, Diehl-Schmid J, Alexopoulos P, Perneczky R, Synofzik M, Just J, Schöls L, Graff C, Thonberg H, Borroni B, Padovani A, Jordanova A, Sarafov S, Tournev I, de Mendonça A, Miltenberger-Miltényi G, Simões do Couto F, Ramirez A, Jessen F, Heneka MT, Gómez-Tortosa E, Danek A, Cras P, Vandenberghe R, De Jonghe P, De Deyn PP, Sleegers K, Cruts M, Van Broeckhoven C, Goeman J, Nuytten D, Smets K, Robberecht W, Damme PV, Bleecker J, Santens P, Dermaut B, Versijpt J, Michotte A, Ivanoiu A, Deryck O, Bergmans B, Delbeck J, Bruyland M, Willems C, Salmon E, Pastor P, Ortega-Cubero S, Benussi L, Ghidoni R, Binetti G, Hernández I, Boada M, Ruiz A, Sorbi S, Nacmias B, Bagnoli S, Sorbi S, Sanchez-Valle R, Llado A, Santana I, Rosário Almeida M, Frisoni GB, Maetzler W, Matej R, Fraidakis MJ, Kovacs GG, Fabrizi GM, Testi S.

Efficacy and Safety of Plasma Exchange with 5% Albumin to Modify Cerebrospinal Fluid and Plasma Amyloid-β Concentrations and Cognition Outcomes in Alzheimer's Disease Patients: A Multicenter, Randomized, Controlled Clinical Trial
J Alzheimers Dis. J Alzheimers Dis. 2017;F.I.: 4,15   doi:56(1):129-143.
Boada M, Anaya F, Ortiz P, Olazarán J, Shua-Haim JR, Obisesan TO, Hernández I, Muñoz J, Buendia M, Alegret M, Lafuente A, Tárraga L, Núñez L, Torres M, Grifols JR, Ferrer I, Lopez OL, Páez A.

Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases

J Neurol Neurosurg Psychiatry. 2017 Feb; F.I.: 6.81   doi:88(2):152-164.

Ferrari R, Wang Y, Vandrovcova J, Guelfi S, Witeolar A, Karch CM, Schork AJ, Fan CC, Brewer JB; International FTD-Genomics Consortium (IFGC), International Parkinson's Disease Genomics Consortium (IPDGC), International Genomics of Alzheimer's Project (IGAP), Momeni P, Schellenberg GD, Dillon WP, Sugrue LP, Hess CP, Yokoyama JS, Bonham LW, Rabinovici GD, Miller BL, Andreassen OA, Dale AM, Hardy J, Desikan RS.


Genome-wide significant risk factors for Alzheimer's disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive impairment
Mol Psychiatry. 2017 Jan; I.F.: 14,5  doi: 10.1038/mp.2016.18. 
Lacour A, Espinosa A, Louwersheimer E, Heilmann S, Hernández I, Wolfsgruber S, Fernández V, Wagner H, Rosende-Roca M, Mauleón A, Moreno-Grau S, Vargas L, Pijnenburg YA, Koene T, Rodríguez-Gómez O, Ortega G, Ruiz S, Holstege H, Sotolongo-Grau O, Kornhuber J, Peters O, Frölich L, Hüll M, Rüther E, Wiltfang J, Scherer M, Riedel-Heller S, Alegret M, Nöthen MM, Scheltens P, Wagner M, Tárraga L, Jessen F, Boada M, Maier W, van der Flier WM, Becker T, Ramirez A, Ruiz A

Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment
Alzheimers Dement. 2016 Aug;12(8):872-81. I.F. 12,41 doi: 10.1016/j.jalz.2016.01.006
Louwersheimer E, Wolfsgruber S, Espinosa A, Lacour A, Heilmann-Heimbach S, Alegret M, Hernández I, Rosende-Roca M, Tárraga L, Boada M, Kornhuber J, Peters O, Frölich L, Hüll M, Rüther E1, Wiltfang J, Scherer M, Riedel-Heller S, Jessen F, Nöthen MM, Maier W, Koene T, Scheltens P, Holstege H, Wagner M, Ruiz A, van der Flier WM, Becker T, Ramirez A.

Beneficial Effects of an Integrated Psychostimulation Program in Patients with Alzheimer's Disease 

J Alzheimers Dis. 2015; I.F.: 4.15  doi:50(2):559-66.

Ibarria M, Alegret M, Valero S, Morera A, Guitart M, Cañabate P, Moreno M, Lara S, Diego S, Hernández J, Tantinyá N, Vera M, Hernández I, Becker JT, Ruíz A, Boada M, Tárraga L.


Registries and Cohorts to Accelerate Early Phase Alzheimer's Trials. A Report from the E.U./U.S. Clinical Trials in Alzheimer's Disease Task Force
J Prev Alzheimers Dis. 2016;3(2):68-74. doi: 10.14283/jpad.2016.97.
Aise P, Touchon J, Andrieu S, Boada M, Doody R, Nosheny RL, Langbaum JB, Schneider L, Hendrix S, Wilcock G, Molinuevo JL, Ritchie C, Ousset P-J, Cummings J, Sperling R, DeKsky ST, Lovestone S, Hampel H, Petersen R, Legrand V, Egan M, Randolph C, Salloway S, Weiner M, Vellas B and Task Force members.

FACEHBI: A Prospective Study Of Risk Factors, Biomarkers and Cognition in a Cohort of Individuals with Subjective Cognitive Decline. Study Rationale and Research Protocols
J Prev Alzheimers Dis. 2017;4(2):100-108. doi: 10.14283/jpad.2016.122.
O. Rodriguez-Gomez, A. Sanabria, A. Perez-Cordon, D. Sanchez-Ruiz, C. Abdelnour, S. Valero, I. Hernandez, M. Rosende-Roca, A. Mauleon, L. Vargas, M. Alegret, A. Espinosa, G. Ortega, M. Guitart, A. Gailhajanet, O. Sotolongo-Grau, S. Moreno-Grau, S. Ruiz, M. Tarragona, J. Serra, E. Martin, E. Peleja, F. Lomeña, F. Campos, A. Vivas, M.Gomez-Chiari, M.A. Tejero, J. Giménez, P. Pesini, M. Sarasa, G.Martinez, A. Ruiz, L. Tarraga, M.Boada.

Whole exome sequencing analysis reveals TRPV3 as a risk factor for cardioembolic stroke

Thromb Haemost. 2016 Nov doi:30;116(6):1165-1171. Epub 2016 Sep 8.

Carrera C, Jiménez-Conde J, Derdak S, Rabionet K, Vives-Bauzá C, Soriano-Tárrega C, Giralt-Steinhauer E, Mola M, Diaz-Navarro RM, Tur S, Muiño E, Gallego-Fabrega C, Beltran S, Roquer J, Ruiz A, Sotolongo-Grau O, Krupinski J, Lee JM, Cruchaga C, Delgado P, Malik R, Worrall BB, Seshadri S, Montaner J, Fernández-Cadenas I1; Metastroke Consortium, ISGC Consortium and Genestroke Consortium.


Alzheimer's disease cerebrospinal fluid biomarkers predict cognitive decline in lewy body dementia
Mov Disord. 2016 Aug;31(8):1203-8. doi: 10.1002/mds.26668. Epub 2016 Jun 14.
Abdelnour C, van Steenoven I, Londos E, Blanc F, Auestad B, Kramberger MG, Zetterberg H, Mollenhauer B, Boada M, Aarsland D; European DLB Consortium

Bapineuzumab for mild to moderate Alzheimer's disease in two global, randomized, phase 3 trials 

Alzheimers Res Ther. 2016 May 12;8(1):18. doi: 10.1186/s13195-016-0189-7

Vandenberghe R, Rinne JO, Boada M, Katayama S, Scheltens P, Vellas B, Tuchman M, Gass A, Fiebach JB, Hill D, Lobello K, Li D, McRae T, Lucas P, Evans I, Booth K, Luscan G, Wyman BT, Hua L, Yang L, Brashear HR, Black RS; Bapineuzumab 3000 and 3001 Clinical Study Investigators. 


Genome research in pre-dementia stages of Alzheimer's disease

Expert Rev Mol Med. 2016 May 30;18:e11. doi: 10.1017/erm.2016.12.

Moreno-Grau S, Ruiz A. Expert Rev 


Total Listing 21

133.82

Exploring APOE genotype effects on AD risk and beta-amyloid burden in individuals with subjective cognitive decline: the FACEHBI study baseline results

Alzheimers Dement. 2018 May;14(5):634-643. F. I.: 9.478. doi: 10.1016/j.jalz.2017.10.005. Epub 2017 Nov 20.

Sonia Moreno –Grau, O. Rodríguez-Gomez, A. Sanabria, A. Perez-Cordon, D. Sánchez-Ruiz, C. Abdelnour, S. Valero, I. Hernández, M. Rosende-Roca, A. Mauleón, L. Vargas, A. Lafuente, S. Gil, M. A. Santos-Santos, M. Alegret, A. Espinosa, G. Ortega, M. Guitart, A. Gailhajanet, I. de Rojas, O. Sotolongo-Grau, S. Ruiz, N. Aguilera, J. Papasey, E. Martín, E. Peleja, Alzheimer’s Disease Neuroimaging Initiative*, F. Lomeña, F. Campos, A. Vivas, M.Gomez-Chiari, M.A. Tejero, J. Giménez, M. Serrano-Ríos, A. Orellana, L. Tárraga, A. Ruiz, M.Boada, on behalf of the FACEHBI study group.


Frontotemporal Lobar Degeneration. Review and update for clinical neurologists

Curr Alzheimer Res. 2018;15(6):511-530. F. I.: 2.952. doi: 10.2174/1567205014666170725130819. Epub 2017 Jul 25.

Hernández I, Fernández MV, Tàrraga L, Boada M, Ruiz A.


Genetic risk for schizophrenia and psychosis in Alzheimer disease

Mol Psychiatry. 2018 Apr;23(4):963-972. F.I.: 13.204. doi: 10.1038/mp.2017.81. Epub 2017 May 2.

DeMichele-Sweet MAA, Weamer EA, Klei L, Vrana DT, Hollingshead DJ, Seltman HJ, Sims R, Foroud T, Hernandez I, Moreno-Grau S, Tárraga L, Boada M, Ruiz A, Williams J, Mayeux R, Lopez OL, Sibille EL, Kamboh MI, Devlin B, Sweet RA.


A phase III randomized trial of gantenerumab in prodromal Alzheimer's disease

Alzheimers Res Ther. 2017 Dec 8;9(1):95. F.I.: 6.154. doi: 10.1186/s13195-017-0318-y.

Ostrowitzki S, Lasser RA, Dorflinger E, Scheltens P, Barkhof F, Nikolcheva T, Ashford E, Retout S, Hofmann C, Delmar P, Klein G, Andjelkovic M, Dubois B, Boada M, Blennow K, Santarelli L, Fontoura P; SCarlet RoAD Investigators.


Retinal Microperimetry: A New Tool for Identifying Type 2 Diabetic Patients at Risk of DevelopingAlzheimer´s Disease

Diabetes. 2017 Dec;66(12):3098-3104. F. I.: 8.684. doi: 10.2337/db17-0382. Epub 2017 Sep 26.

Ciudin A, Simó-Servat O, Hernández C, Arcos G, Diego S, Sanabria Á, Sotolongo Ó, Hernández I, Boada M, Simó R.


18F PET with florbetaben for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)

Cochrane Database Syst Rev. 2017 Nov 22;11:CD012883. F.I.: 6.12. doi: 10.1002/14651858.CD012883.

Martínez G, Vernooij RW, Fuentes Padilla P, Zamora J, Flicker L, Bonfill Cosp X.


18F PET with flutemetamol for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)

Cochrane Database Syst Rev. 2017 Nov 22;11:CD012884. F.I.: 6.12. doi: 10.1002/14651858.CD012884.

Martínez G, Vernooij RW, Fuentes Padilla P, Zamora J, Flicker L, Bonfill Cosp X.


18F PET with florbetapir for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)

Cochrane Database Syst Rev. 2017 Nov 22;11:CD012216. F.I.: 6.12. doi: 10.1002/14651858.CD012216.pub2.

Martínez G, Vernooij RW, Fuentes Padilla P, Zamora J, Bonfill Cosp X, Flicker L.


Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis

JAMA Neurol. 2017 Oct 1;74(10):1178-1189. F. I.: 10.03. doi: 10.1001/jamaneurol.2017.2188.

Neu SC, Pa J, Kukull W, Beekly D, Kuzma A, Gangadharan P, Wang LS, Romero K, Arneric SP, Redolfi A, Orlandi D, Frisoni GB, Au R, Devine S, Auerbach S, Espinosa A, Boada M, Ruiz A, Johnson SC, Koscik R, Wang JJ, Hsu WC, Chen Y, Toga AW.


Registries and Cohorts to Accelerate Early Phase Alzheimer’s Trials. A Report from the E.U./U.S. Clinical Trials in Alzheimer’s Disease Task Force

J Prev Alz Dis 2016;3(2):68-74. doi: 10.14283/jpad.2016.97

P. Aisen, J. Touchon, S. Andrieu, M. Boada, R. Doody, R.L. Nosheny, J.B. Langbaum, L. Schneider, S. Hendrix, G. Wilcock, J.L. Molinuevo, C. Ritchie, P.-J. Ousset, J. Cummings, R. Sperling, S.T. DeKosky, S. Lovestone, H. Hampel, R. Petersen, V. Legrand, M. Egan, C. Randolph, S. Salloway, M. Weiner, B. Vellas, and Task Force Members.


A physical model for dementia

Physica A. 2017 Apr 15;472:86-93. doi:10.1016/j.physa.2016.12.086. Epub 2017 Jan 4.

O. Sotolongo-Costa, L.M. Gaggero-Sager, J.T. Becker, F. Maestuf, O. Sotolongo-Grau, for the Alzheimer’s Disease Neuroimaging Initiative.


The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: An EADC study

Alzheimers Dement. 2017 Sep;13(9):1013-1023. I.F.: 11,619. doi: 10.1016/j.jalz.2017.01.019. Epub 2017

Mar 3 Bosco P, Redolfi A, Bocchetta M, Ferrari C, Mega A, Galluzzi S, Austin M, Chincarini A, Collins DL, Duchesne S, Maréchal B, Roche A, Sensi F, Wolz R, Alegret M, Assal F, Balasa M, Bastin C, Bougea A, Emek-Savaş DD, Engelborghs S, Grimmer T, Grosu G, Kramberger MG, Lawlor B, Mandic Stojmenovic G, Marinescu M, Mecocci P, Molinuevo JL, Morais R, Niemantsverdriet E, Nobili F, Ntovas K, O'Dwyer S, Paraskevas GP, Pelini L, Picco A, Salmon E, Santana I, Sotolongo-Grau O, Spiru L, Stefanova E, Popovic KS, Tsolaki M, Yener GG, Zekry D, Frisoni GB.


Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Nat Genet. 2017 Sep;49(9):1373-1384. F.I.: 27.959 (2 years). doi: 10.1038/ng.3916. Epub 2017 Jul 17.

Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sánchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Jr WTL, Fairchild TJ, Bossù P, Lopez OL, Frosch MP, Sacchinelli E, Ghetti B, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Dunstan M, Braddel A, Thomas C, Meggy A, Marshall R, Gerrish A, Chapman J, Aguilar M, Taylor S, Hill M, Fairén MD, Hodges A, Vellas B, Soininen H, Kloszewska I, Daniilidou M, Uphill J, Patel Y, Hughes JT, Lord J, Turton J, Hartmann AM, Cecchetti R, Fenoglio C, Serpente M, Arcaro M, Caltagirone C, Orfei MD, Ciaramella A, Pichler S, Mayhaus M, Gu W, Lleó A, Fortea J, Blesa R, Barber IS, Brookes K, Cupidi C, Maletta RG, Carrell D, Sorbi S, Moebus S, Urbano M, Pilotto A, Kornhuber J, Bosco P, Todd S, Craig D, Johnston J, Gill M, Lawlor B, Lynch A, Fox NC, Hardy J; ARUK Consortium, Albin RL, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Baldwin CT, Barnes LL, Barral S, Beach TG, Becker JT, Bigio EH, Bird TD, Boeve BF, Bowen JD, Boxer A, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Carroll SL, Diaz CC, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, Dick M, Duara R, Evans DA, Faber KM, Fallon KB, Fardo DW, Farlow MR, Ferris S, Foroud TM, Galasko DR, Gearing M, Geschwind DH, Gilbert JR, Graff-Radford NR, Green RC, Growdon JH, Hamilton RL, Harrell LE, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Abner E, Jin LW, Jun G, Karydas A, Kaye JA, Kim R, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lunetta KL, Lyketsos CG, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Morris JC, Murrell JR, Myers AJ, O'Bryant S, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Perry W, Peskind E, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, Sager MA, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Garzia F, Golamaully F, Septier G, Engelborghs S, Vandenberghe R, De Deyn PP, Fernadez CM, Benito YA, Thonberg H, Forsell C, Lilius L, Kinhult-Stählbom A, Kilander L, Brundin R, Concari L, Helisalmi S, Koivisto AM2, Haapasalo A, Dermecourt V, Fievet N, Hanon O, Dufouil C, Brice A, Ritchie K, Dubois B, Himali JJ, Keene CD, Tschanz J, Fitzpatrick AL, Kukull WA, Norton M, Aspelund T, Larson EB, Munger R, Rotter JI, Lipton RB, Bullido M, Hofman A, Montine TJ, Coto E, Boerwinkle E, Petersen RC, Alvarez V, Rivadeneira F, Reiman EM, Gallo M, O'Donnell C, Reisch JS, Bruni AC, Royall DR, Dichgans M, Sano M, Galimberti D, St George-Hyslop P, Scarpini E, Tsuang DW, Mancuso M, Bonuccelli U, Winslow AR, Daniele A, Wu CK; GERAD/PERADES, CHARGE, ADGC, EADI, Peters O, Nacmias B, Riemenschneider M, Heun R, Brayne C, Rubinsztein DC, Bras J, Guerreiro R, Al-Chalabi A, Shaw CE, Collinge J, Mann D, Tsolaki M, Clarimón J, Sussams R, Lovestone S, O'Donovan MC, Owen MJ, Behrens TW, Mead S, Goate AM, Uitterlinden AG, Holmes C1, Cruchaga C, Ingelsson M, Bennett DA, Powell J, Golde TE, Graff C, De Jager PL, Morgan K, Ertekin-Taner N, Combarros O, Psaty BM, Passmore P, Younkin SG, Berr C, Gudnason V, Rujescu D, Dickson DW, Dartigues JF, DeStefano AL, Ortega-Cubero S, Hakonarson H, Campion D, Boada M, Kauwe JK, Farrer LA, Van Broeckhoven C, Ikram MA, Jones L, Haines JL, Tzourio C, Launer LJ, Escott-Price V, Mayeux R, Deleuze JF, Amin N, Holmans PA, Pericak-Vance MA, Amouyel P, van Duijn CM, Ramirez A, Wang LS, Lambert JC, Seshadri S, Williams J, Schellenberg GD.


Mapping the Health Information Landscape in a Rural, Culturally Diverse Region: Implications for Interventions to Reduce Information Inequality

J Prim Prev. 2017 Aug;38(4):345-362. I.F.: 1,33. doi: 10.1007/s10935-017-0466-7.

Ramírez AS, Estrada E, Ruiz A.


Type 2 diabetes is an independent risk factor for dementia conversion in patients with mild cognitive impairment

J Diabetes Complications. 2017 Aug;31(8):1272-1274. F.I.: 2.73. doi: 10.1016/j.jdiacomp.2017.04.018. Epub 2017 Apr 19.

Ciudin A, Espinosa A, Simó-Servat O, Ruiz A, Alegret M, Hernández C, Boada M, Simó R.


Sembragiline in Moderate Alzheimer's Disease: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Trial (MAyflOwer RoAD)

J Alzheimers Dis. 2017;58(4):1217-1228. F.I.: 3.731. doi: 10.3233/JAD-161309.

Nave S, Doody RS, Boada M, Grimmer T, Savola JM, Delmar P, Pauly-Evers M, Nikolcheva T, Czech C, Borroni E, Ricci B, Dukart J, Mannino M, Carey T, Moran E, Gilaberte I, Muelhardt NM, Gerlach I, Santarelli L, Ostrowitzki S, Fontoura P.


Challenges for Service Robots-Requirements of Elderly Adults with Cognitive Impairments

Front Neurol. 2017 Jun 1;8:228. F.I.: 6.4. doi: 10.3389/fneur.2017.00228. eCollection 2017.

Korchut A, Szklener S, Abdelnour C, Tantinya N, Hernández-Farigola J, Ribes JC, Skrobas U, Grabowska-Aleksandrowicz K, Szczęśniak-Stańczyk D, Rejdak K.


Social Representation of Dementia: An Analysis of 5,792 Consecutive Cases Evaluated in a Memory Clinic

J Alzheimers Dis. 2017;58(4):1099-1108. F.I.: 3.731. doi: 10.3233/JAD-161119.

Cañabate P, Martínez G, Rosende-Roca M, Moreno M, Preckler S, Valero S, Sotolongo O, Hernández I, Alegret M, Ortega G, Espinosa A, Mauleón A, Vargas L, Rodríguez O, Abdelnour C, Sánchez D, Martín E, Ruiz A, Tárraga L, Boada M..


Cognitive Composites Domain Scores Related to Neuroimaging Biomarkers within Probable-Amnestic Mild Cognitive Impairment-Storage Subtype

J Alzheimers Dis. 2017;57(2):447-459. F.I.: 3.731. doi: 10.3233/JAD-161223.

Espinosa A, Alegret M, Pesini P, Valero S, Lafuente A, Buendía M, San José I, Ibarria M, Tejero MA, Giménez J, Ruiz S, Hernández I, Pujadas F, Martínez-Lage P, Munuera J, Arbizu J, Tárraga L, Hendrix SB, Ruiz A, Becker JT, Landau SM, Sotolongo-Grau O, Sarasa M, Boada M.


Impact of Recruitment Methods in Subjective Cognitive Decline

J Alzheimers Dis. 2017;57(2):625-632. F.I.: 3.731. doi: 10.3233/JAD-160915.

Abdelnour C, Rodríguez-Gómez O, Alegret M, Valero S, Moreno-Grau S, Sanabria Á, Hernández I, Rosende-Roca M, Vargas L, Mauleón A, Sánchez D, Espinosa A, Ortega G, Pérez-Cordón A, Diego S, Gailhajanet A, Guitart M, Sotolongo-Grau Ó, Ruiz A, Tárraga L, Boada M.


Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis

JAMA Neurol. 2017 Oct 1;74(10):1178-1189.  F. I.: 10.03   doi: 10.1001/jamaneurol.2017.2188.

J, Kukull W, Beekly D, Kuzma A, Gangadharan P, Wang LS, Romero K, Arneric SP, Redolfi A, Orlandi D, Frisoni GB, Au R, Devine S, Auerbach S, Espinosa A, Boada M, Ruiz A, Johnson SC, Koscik R, Wang JJ, Hsu WC, Chen Y, Toga AW.


Total Listing 34

211,45

Severity dependent distribution of impairments in PSP and CBS: Interactive visualizations

Parkinsonism and Related Disorders. 2018 Sep 4. pii: S1353-8020(18)30384-5. F.I.: 4.721 doi: 10.1016/j.parkreldis.2018.08.025 

Brittain C1, McCarthy A2, Irizarry MC3, McDermott D4, Biglan K3, Höglinger GU5, Lorenzl S6, Del Ser T7, Boxer AL4; AL-108-231 Study Group; PROPSPERA investigators; 4RNTI-1authors; Tau Restoration on PSP (TAUROS) Investigators.


Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2018 Sep 22;10:595-598 doi: 10.1016/j.dadm.2018.08.008.
Peloso GM1, van der Lee SJ2; International Genomics of Alzheimer's Project (IGAP), Destefano AL1,3,4, Seshardi S3,4,5.

Anticancer Agents in Medicine Chemistry  

Anticancer Agents Med Chem. 2018;18(4):591-596. doi: 10.2174/1871520618666180228123406.     

Ruiz DS1, Luksch H2, Sifringer M3, Temme A4, Staufner C5, Rzeski W6,7, Marzahn J2, Grabarska A8, Ikonomidou C9, Stepulak A8.


AMPA Receptor Antagonist CFM-2 Decreases Survivin Expression in Cancer Cells

Anticancer Agents in Medicine Chemistry. 2018;18(4):591-596 F.I.: 2.556 doi: 10.2174/1871520618666180228123406.

Ruiz DS, Luksch H, Sifringer M, Temme A, Staufner C, Rzeski W, Marzahn J, Grabarska A, Ikonomidou C, Stepulak A.

Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia

Alzheimers Dement. 2018 Dec 13. pii: S1552-5260(18)33563-5. F.I. 12,74 doi: 10.1016/j.jalz.2018.10.003

Slot RER1, Sikkes SAM2, Berkhof J3, Brodaty H4, Buckley R5, Cavedo E6, Dardiotis E7, Guillo-Benarous F8, Hampel H6, Kochan NA9, Lista S6, Luck T10, Maruff P11, Molinuevo JL12, Kornhuber J13, Reisberg B8, Riedel-Heller SG14, Risacher SL15, Roehr S16, Sachdev PS9, Scarmeas N17, Scheltens P1, Shulman MB8, Saykin AJ15, Verfaillie SCJ1, Visser PJ18, Vos SJB19, Wagner M20, Wolfsgruber S20, Jessen F21; Alzheimer's Disease Neuroimaging Initiative, the DESCRIPA working group, the INSIGHT-preAD study group, on behalf of the SCD-I working group, van der Flier WM22.


Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

Nat Med. 2018 Dec 3. F.I. 32,62 doi: 10.1038/s41591-018-0223-3

Swarup V1, Hinz FI1, Rexach JE1, Noguchi KI2, Toyoshiba H2, Oda A2, Hirai K2, Sarkar A1, Seyfried NT3,4, Cheng C5, Haggarty SJ5; International Frontotemporal Dementia Genomics Consortium, Grossman M6, Van Deerlin VM7, Trojanowski JQ7, Lah JJ4, Levey AI4, Kondou S2, Geschwind DH8,9,10.


Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundació ACE Healthy Brain Initiative (FACEHBI)

Alzheimers Res Ther. 2018 Nov 29;10(1):119. F.I. 5.015 doi: 10.1186/s13195-018-0444-1

de Rojas I, Romero J, Rodríguez-Gomez O, Pesini P, Sanabria A, Pérez-Cordon A, Abdelnour C, Hernández I, Rosende-Roca M, Mauleón A, Vargas L, Alegret M, Espinosa A, Ortega G, Gil S, Guitart M, Gailhajanet A, Santos-Santos MA, Moreno-Grau S, Sotolongo-Grau O, Ruiz S, Montrreal L, Martín E, Pelejà E, Lomeña F, Campos F, Vivas A, Gómez-Chiari M, Tejero MA, Giménez J, Pérez-Grijalba V, Marquié GM, Monté-Rubio G, Valero S, Orellana A, Tárraga L, Sarasa M, Ruiz A*, Boada M; FACEHBI study. 


Plasma Aβ42/40 Ratio Detects Early Stages of Alzheimer’s Disease and Correlates with CSF and Neuroimaging Biomarkers in the AB255 Study

J Prev Alzheimers Dis. 2019;6(1):34-41. doi: 10.14283/jpad.2018.41.

V. Pérez-Grijalba, J. Romero, P. Pesini, L. Sarasa, I. Monleón, I. San-José, J. Arbizu, P. Martínez-Lage, J. Munuera, A. Ruiz, L. Tárraga, M. Boada, M. Sarasa, on behalf of The AB255 Study Group.


Usefulness of peripapillary nerve fiber layer thickness assessed by optical coherence tomography as a biomarker for Alzheimer's disease 

Nature Scientific Reports. 2018 Nov 5;8(1):16345 F.I.: 4,122  doi: 10.1038/s41598-018-34577-3.

Sánchez D*, Castilla-Marti M, Rodríguez-Gómez O, Valero S, Piferrer A, Martínez G, Martínez J, Serra J, Moreno-Grau S, Hernández-Olasagarre B, De Rojas I, Hernández I, Abdelnour C, Rosende-Roca M, Vargas L, Mauleón A, Santos-Santos MA, Alegret M, Ortega G, Espinosa A, Pérez-Cordón A, Sanabria Á, Ciudin A, Simó R, Hernández C, Villaoslada P, Ruiz A, Tàrraga L, Boada M. 


Exploring Genetic Associations of Alzheimer’s Disease Loci With Mild Cognitive Impairment Neurocognitive Endophenotypes

Frontiers in Aging Neuroscience, 2018 Oct 30;10:340.  F.I.: 3.582  doi:10.3389/fnagi.2018.00340. 

Espinosa A, Hernández-Olasagarre B, Moreno-Grau S, Kleineidam L, Heilmann-Heimbach S, Hernández I, Wolfsgruber S, Wagner H, Rosende-Roca M, Mauleón A, Vargas L, Lafuente A, Rodríguez-Gómez O, Abdelnour C, Gil S, Marquié M, Santos-Santos MA, Sanabria Á, Ortega G, Monté-Rubio G, Pérez A, Ibarria M, Ruiz S, Kornhuber J, Peters O, Frölich L, Hüll M, Wiltfang J, Luck T, Riedel-Heller S, Montrreal L, Cañabate P, Moreno M, Preckler S, Aguilera N, de Rojas I, Orellana A, Alegret M, Valero S, Nöthen MM, Wagner M, Jessen F, Tárraga L, Boada M, Ramírez A, Ruiz A*.  


Pharmacodynamics of atabecestat (JNJ-54861911), an oral BACE1 inhibitor in patients with early Alzheimer's disease: randomized, double-blind, placebo-controlled study

Alzheimers Res Ther. 2018 Aug 23;10(1):85. F.I. 5.015. doi: 10.1186/s13195-018-0415-6.

Timmers M1,2, Streffer JR3,4,5, Russu A3, Tominaga Y6, Shimizu H6, Shiraishi A6, Tatikola K7, Smekens P3, Börjesson-Hanson A8, Andreasen N9, Matias-Guiu J10, Baquero M11, Boada M12, Tesseur I3, Tritsmans L3, Van Nueten L3, Engelborghs S4,13.


Analysis of shared heritability in common disorders of the brain

Science. 2018 Jun 22;360(6395). pii: eaap8757 F.I. 41.058. doi: 10.1126/science.aap8757

Brainstorm Consortium, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ, Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore P, Morgan K, Nöthen MM, Rossor M, Lupton MK, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis JC, Ruiz A, Boada M, Seshadri S, Beiser A, Rice K, van der Lee SJ, De Jager PL, Geschwind DH, Riemenschneider M, Riedel-Heller S, Rotter JI, Ransmayr G, Hyman BT, Cruchaga C, Alegret M, Winsvold B, Palta P, Farh KH, Cuenca-Leon E, Furlotte N, Kurth T, Ligthart L, Terwindt GM, Freilinger T, Ran C, Gordon SD, Borck G, Adams HHH, Lehtimäki T, Wedenoja J, Buring JE, Schürks M, Hrafnsdottir M, Hottenga JJ, Penninx B, Artto V, Kaunisto M, Vepsäläinen S, Martin NG, Montgomery GW, Kurki MI, Hämäläinen E, Huang H, Huang J, Sandor C, Webber C, Muller-Myhsok B, Schreiber S, Salomaa V, Loehrer E, Göbel H, Macaya A, Pozo-Rosich P, Hansen T, Werge T, Kaprio J, Metspalu A, Kubisch C, Ferrari MD, Belin AC, van den Maagdenberg AMJM, Zwart JA, Boomsma D, Eriksson N, Olesen J, Chasman DI, Nyholt DR, Avbersek A, Baum L, Berkovic S, Bradfield J, Buono R, Catarino CB, Cossette P, De Jonghe P, Depondt C, Dlugos D, Ferraro TN, French J, Hjalgrim H, Jamnadas-Khoda J, Kälviäinen R, Kunz WS, Lerche H, Leu C, Lindhout D, Lo W, Lowenstein D, McCormack M, Møller RS, Molloy A, Ng PW, Oliver K, Privitera M, Radtke R, Ruppert AK, Sander T, Schachter S, Schankin C, Scheffer I, Schoch S, Sisodiya SM, Smith P, Sperling M, Striano P, Surges R, Thomas GN, Visscher F, Whelan CD, Zara F, Heinzen EL, Marson A, Becker F, Stroink H, Zimprich F, Gasser T, Gibbs R, Heutink P, Martinez M, Morris HR, Sharma M, Ryten M, Mok KY, Pulit S, Bevan S, Holliday E, Attia J, Battey T, Boncoraglio G, Thijs V, Chen WM, Mitchell B, Rothwell P, Sharma P, Sudlow C, Vicente A, Markus H, Kourkoulis C, Pera J, Raffeld M, Silliman S, Boraska Perica V, Thornton LM, Huckins LM, William Rayner N, Lewis CM, Gratacos M, Rybakowski F, Keski-Rahkonen A, Raevuori A, Hudson JI, Reichborn-Kjennerud T, Monteleone P, Karwautz A, Mannik K, Baker JH, O'Toole JK, Trace SE, Davis OSP, Helder SG, Ehrlich S, Herpertz-Dahlmann B, Danner UN, van Elburg AA, Clementi M, Forzan M, Docampo E, Lissowska J, Hauser J, Tortorella A, Maj M, Gonidakis F, Tziouvas K, Papezova H, Yilmaz Z, Wagner G, Cohen-Woods S, Herms S, Julià A, Rabionet R, Dick DM, Ripatti S, Andreassen OA, Espeseth T, Lundervold AJ, Steen VM, Pinto D, Scherer SW, Aschauer H, Schosser A, Alfredsson L, Padyukov L, Halmi KA, Mitchell J, Strober M, Bergen AW, Kaye W, Szatkiewicz JP, Cormand B, Ramos-Quiroga JA, Sánchez-Mora C, Ribasés M, Casas M, Hervas A, Arranz MJ, Haavik J, Zayats T, Johansson S, Williams N, Dempfle A, Rothenberger A, Kuntsi J, Oades RD, Banaschewski T, Franke B, Buitelaar JK, Arias Vasquez A, Doyle AE, Reif A, Lesch KP, Freitag C, Rivero O, Palmason H, Romanos M, Langley K, Rietschel M, Witt SH, Dalsgaard S, Børglum AD, Waldman I, Wilmot B, Molly N, Bau CHD, Crosbie J, Schachar R, Loo SK, McGough JJ, Grevet EH, Medland SE, Robinson E, Weiss LA, Bacchelli E, Bailey A, Bal V, Battaglia A, Betancur C, Bolton P, Cantor R, Celestino-Soper P, Dawson G, De Rubeis S, Duque F, Green A, Klauck SM, Leboyer M, Levitt P, Maestrini E, Mane S, De-Luca DM, Parr J, Regan R, Reichenberg A, Sandin S, Vorstman J, Wassink T, Wijsman E, Cook E, Santangelo S, Delorme R, Rogé B, Magalhaes T, Arking D, Schulze TG, Thompson RC, Strohmaier J, Matthews K, Melle I, Morris D, Blackwood D, McIntosh A, Bergen SE, Schalling M, Jamain S, Maaser A, Fischer SB, Reinbold CS, Fullerton JM, Guzman-Parra J, Mayoral F, Schofield PR, Cichon S, Mühleisen TW, Degenhardt F, Schumacher J, Bauer M, Mitchell PB, Gershon ES, Rice J, Potash JB, Zandi PP, Craddock N, Ferrier IN, Alda M, Rouleau GA, Turecki G, Ophoff R, Pato C, Anjorin A, Stahl E, Leber M, Czerski PM, Cruceanu C, Jones IR, Posthuma D, Andlauer TFM, Forstner AJ, Streit F, Baune BT, Air T, Sinnamon G, Wray NR, MacIntyre DJ, Porteous D, Homuth G, Rivera M, Grove J, Middeldorp CM, Hickie I, Pergadia M, Mehta D, Smit JH, Jansen R, de Geus E, Dunn E, Li QS, Nauck M, Schoevers RA, Beekman AT, Knowles JA, Viktorin A, Arnold P, Barr CL, Bedoya-Berrio G, Bienvenu OJ, Brentani H, Burton C, Camarena B, Cappi C, Cath D, Cavallini M, Cusi D, Darrow S, Denys D, Derks EM, Dietrich A, Fernandez T, Figee M, Freimer N, Gerber G, Grados M, Greenberg E, Hanna GL, Hartmann A, Hirschtritt ME, Hoekstra PJ, Huang A, Huyser C, Illmann C, Jenike M, Kuperman S, Leventhal B, Lochner C, Lyon GJ, Macciardi F, Madruga-Garrido M, Malaty IA, Maras A, McGrath L, Miguel EC, Mir P, Nestadt G, Nicolini H, Okun MS, Pakstis A, Paschou P, Piacentini J, Pittenger C, Plessen K, Ramensky V, Ramos EM, Reus V, Richter MA, Riddle MA, Robertson MM, Roessner V, Rosário M, Samuels JF, Sandor P, Stein DJ, Tsetsos F, Van Nieuwerburgh F, Weatherall S, Wendland JR, Wolanczyk T, Worbe Y, Zai G, Goes FS, McLaughlin N, Nestadt PS, Grabe HJ, Depienne C, Konkashbaev A, Lanzagorta N, Valencia-Duarte A, Bramon E, Buccola N, Cahn W, Cairns M, Chong SA, Cohen D, Crespo-Facorro B, Crowley J, Davidson M, DeLisi L, Dinan T, Donohoe G, Drapeau E, Duan J, Haan L, Hougaard D, Karachanak-Yankova S, Khrunin A, Klovins J, Kučinskas V, Lee Chee Keong J, Limborska S, Loughland C, Lönnqvist J, Maher B, Mattheisen M, McDonald C, Murphy KC, Nenadic I, van Os J, Pantelis C, Pato M, Petryshen T, Quested D, Roussos P, Sanders AR, Schall U, Schwab SG, Sim K, So HC, Stögmann E, Subramaniam M, Toncheva D, Waddington J, Walters J, Weiser M, Cheng W, Cloninger R, Curtis D, Gejman PV, Henskens F, Mattingsdal M, Oh SY, Scott R, Webb B, Breen G, Churchhouse C, Bulik CM, Daly M, Dichgans M, Faraone SV, Guerreiro R, Holmans P, Kendler KS, Koeleman B, Mathews CA, Price A, Scharf J, Sklar P, Williams J, Wood NW, Cotsapas C, Palotie A, Smoller JW, Sullivan P, Rosand J, Corvin A, Neale BM.


Systematic Screening of Ubiquitin/p62 Aggregates in Cerebellar Cortex Expands the Neuropathological Phenotype of the C9orf72 Expansion Mutation

J Neuropathol Exp Neurol. 2018 Jun 7 F.I.:3.490. doi: 10.1093/jnen/nly047

Ramos-Campoy O1,2, Ávila-Polo R1,3, Grau-Rivera O1,2, Antonell A2, Clarimón J4,5, Rojas-García R6, Charif S1, Santiago-Valera V1, Hernandez I7, Aguilar M8, Almenar C9, Lopez-Villegas D10, Bajo L11, Pastor P8, Van der Zee J12, Lladó A2, Sanchez-Valle R1,2, Gelpi E1,13.


A comparison of various MRI feature types for characterizing whole brain anatomical differences using linear pattern recognition methods

Neuroimage. 2018 Jun 2. pii: S1053-8119(18)30491-9 F.I.: 5.426. doi: 10.1016/j.neuroimage.2018.05.065.

 Monté-Rubio GC1, Falcón C2, Pomarol-Clotet E3, Ashburner J4.


Genome-wide significant risk factors on chromosome 19 and the APOE locus

Oncotarget. 2018 May 15;9(37):24590-24600. F.I.: 5.426. doi: 10.18632/oncotarget.25083.

Moreno-Grau S1, Hernández I1, Heilmann-Heimbach S2,3, Ruiz S1, Rosende-Roca M1, Mauleón A1, Vargas L1, Rodríguez-Gómez O1, Alegret M1, Espinosa A1, Ortega G1, Aguilera N1, Abdelnour C1, Neuroimaging Initiative AD1,2,3,4,5,6,7,8,9, Gil S1, Maier W4,5, Sotolongo-Grau O1, Tárraga L1, Ramirez A2,4,6, López-Arrrieta J7, Antúnez C8, Serrano-Ríos M9, Boada M1, Ruiz A1.


Meta-analysis of genetic association with diagnosed Alzheimer's disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing

BioRxiv. 10.1101/294629 doi:10.1101/294629

Brian W. Kunkle, Benjamin Grenier-Boley, Rebecca Sims, Joshua C. Bis, Adam C. Naj, Anne Boland, Maria Vronskaya, Sven J van der Lee, Alex Amlie-Wolf, Celine Bellenguez, Aura Frizatti, Vincent Chouraki, Alzheimer's Disease Genetics Consortium (ADGC), European Alzheimer's Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in Alzheimer's Disease Consortium (GERAD/PERADES), Helena Schmidt, Hakon Hakonarson, Ron Munger, Reinhold Schmidt, Lindsay A. Farrer, Christine Van Broeckhoven, Michael C. O'Donovan, Anita L. Destefano, Lesley Jones, Jonathan L. Haines, Jean-Francois Deleuze, Michael J. Owen, Vilmundur Gudnason, Richard P. Mayeux, Valentina Escott-Price, Bruce M. Psaty, Agustin Ruiz, Alfredo Ramirez, Li-San Wang, Cornelia M. van Duijn, Peter A. Holmans, Sudha Seshadri, Julie Williams, Philippe Amouyel, Gerard D. Schellenberg, Jean-Charles Lambert, Margaret A. Pericak-Vance. BioRxiv.


Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort

Neurobiol Aging. 2018 Feb;62:245.e1-245.e7 F.I.: 4.454. doi: 10.1016/j.neurobiolaging.2017.10.012. Epub 2017 Oct 25

Verheijen J1, van der Zee J1, Gijselinck I1, Van den Bossche T2, Dillen L1, Heeman B1, Gómez-Tortosa E3, Lladó A4, Sanchez-Valle R4, Graff C5, Pastor P6, Pastor MA7, Benussi L8, Ghidoni R8, Binetti G9, Clarimon J10, de Mendonça A11, Gelpi E12, Tsolaki M13, Diehl-Schmid J14, Nacmias B15, Almeida MR16, Borroni B17, Matej R18, Ruiz A19, Engelborghs S20, Vandenberghe R21, De Deyn PP20, Cruts M1, Van Broeckhoven C22, Sleegers K23; BELNEU Consortium; EU EOD Consortium.


CXCR4 involvement in neurodegenerative diseases

Transl Psychiatry. 2018 Apr 11;8(1):73. F.I.: 4.691. doi: 10.1038/s41398-017-0049-7.

Bonham LW1, Karch CM2, Fan CC3, Tan C4, Geier EG1, Wang Y5, Wen N2, Broce IJ4, Li Y4, Barkovich MJ4, Ferrari R6, Hardy J6, Momeni P7, Höglinger G8,9, Müller U10, Hess CP4, Sugrue LP4, Dillon WP4, Schellenberg GD11, Miller BL1, Andreassen OA5, Dale AM3,12, Barkovich AJ4, Yokoyama JS1, Desikan RS13; International FTD-Genomics Consortium (IFGC); International Parkinson’s Disease Genetics Consortium (IPDGC); International Genomics of Alzheimer’s Project (IGAP).


Author Correction: Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS

Sci Rep. 2018 May 14;8(1):7789. F.I.: 4.122. doi: 10.1038/s41598-018-21308-x.

Taskesen E1,2, Mishra A1, van der Sluis S1, Ferrari R3; International FTD-Genomics Consortium, Veldink JH4, van Es MA4, Smit AB5, Posthuma D1,2, Pijnenburg Y6.


Protein network analysis reveals selectively vulnerable regions and biological processes in FTD

Neurology Genetics. 2018 Oct 1;4(5):e266. doi: 10.1212/NXG.0000000000000266.

Bonham LW1, Steele NZR1, Karch CM1, Manzoni C1, Geier EG1, Wen N1, Ofori-Kuragu A1, Momeni P1, Hardy J1, Miller ZA1, Hess CP1, Lewis P1, Miller BL1, Seeley WW1, Baranzini SE1, Desikan RS1, Ferrari R1, Yokoyama JS1; International FTD-Genomics Consortium (IFGC).


Increased Albumin Oxidation in Cerebrospinal Fluid and Plasma from Alzheimer's Disease Patients

J Alzheimers Dis. 2018 May 16. F.I.: 3.476. doi: 10.3233/JAD-180243

Costa M1, Horrillo R1, Ortiz AM1, Pérez A1, Mestre A1, Ruiz A2, Boada M2,3, Grancha S1.


Trial of Solanezumab for Mild Dementia Due to Alzheimer's Disease

N Engl J Med. 2018 Jan 25;378(4):321-330. F.I.: 79.258. doi: 10.1056/NEJMoa1705971.

Honig LS, Vellas B, Woodward M, Boada M, Bullock R, Borrie M, Hager K, Andreasen N, Scarpini E, Liu-Seifert H, Case M, Dean RA, Hake A, Sundell K, Poole Hoffmann V, Carlson C, Khanna R, Mintun M, DeMattos R, Selzler KJ, Siemers E.


Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies

PLoS Med. 2018 Jan 9;15(1):e1002487. F.I.: 11.675. doi: 10.1371/journal.pmed.1002487. eCollection 2018 Jan.

Broce I, Karch CM, Wen N, Fan CC, Wang Y, Hong Tan C, Kouri N, Ross OA, Höglinger GU, Muller U, Hardy J; International FTD-Genomics Consortium, Momeni P, Hess CP, Dillon WP, Miller ZA, Bonham LW, Rabinovici GD, Rosen HJ, Schellenberg GD, Franke A, Karlsen TH, Veldink JH, Ferrari R, Yokoyama JS, Miller BL, Andreassen OA, Dale AM, Desikan RS, Sugrue LP.


Longitudinal Neuroimaging Analysis in Mild-Moderate Alzheimer's Disease Patients Treated with Plasma Exchange with 5% Human Albumin

J Alzheimers Dis. 2018;61(1):321-332. F.I.: 3.476. doi: 10.3233/JAD-170693.

Cuberas-Borrós G, Roca I, Boada M, Tárraga L, Hernández I, Buendia M, Rubio L, Torres G, Bittini Á, Guzmán-de-Villoria JA, Pujadas F, Torres M, Núñez L, Castell J, Páez A.


Safety, tolerability and immunogenicity of an active anti-Aβ40 vaccine (ABvac40) in patients with Alzheimer’s disease: a randomised, double-blind, placebo-controlled, phase I trial

Alzheimers Res Ther. 2018 Jan 29;10(1):12. F.I.: 5.015. doi: 10.1186/s13195-018-0340-8

Ana-María Lacosta, María Pascual-Lucas, Pedro Pesini, Diego Casabona, Virginia Pérez-Grijalba, Iván Marcos-Campos, Leticia Sarasa, Jesus Canudas, Hassnae Badi, Inmaculada Monleón, Itziar San-José, Josep Munuera, Octavio Rodríguez-Gómez, Carla Abdelnour, Asunción Lafuente, Mar Buendía, Mercè Boada, Lluis Tárraga, Agustín Ruiz, Manuel Sarasa.


The Spanish version of Face-Name Associative Memory Exam (S-FNAME) performance is related to amyloid burden in Subjective Cognitive Decline

Sci Rep. 2018 Feb 28;8(1):3828. F.I.: 4.122. doi: 10.1038/s41598-018-21644-y

Sanabria A, Alegret M, Rodriguez-Gomez O, Valero S, Sotolongo-Grau O, Monté-Rubio G, Abdelnour C, Espinosa A, Ortega G, Perez-Cordon A, Gailhajanet A, Hernandez I, Rosende-Roca M, Vargas L, Mauleon A, Sanchez D, Martin E, Rentz DM, Lomeña F, Ruiz A, Tarraga L, Boada M; FACEHBI study group.


Rare nonsynonymous variants in SORT1 are associated with increased risk for frontotemporaldementia

Neurobiol Aging. 2018 Jun;66:181.e3-181.e10. F.I.: 4.454. doi:10.1016/j.neurobiolaging.2018.02.011

Philtjens S, Van Mossevelde S, van der Zee J, Wauters E, Dillen L, Vandenbulcke M, Vandenberghe R, Ivanoiu A, Sieben A, Willems C7, Benussi L, Ghidoni R, Binetti G, Borroni B, Padovani A, Pastor P, Diez-Fairen M, Aguilar M, de Mendonça A, Miltenberger-Miltényi G, Hernández I, Boada M, Ruiz A, Nacmias B, Sorbi S, Almeida MR, Santana I, Clarimón J, Lleó A, Frisoni GB, Sanchez-Valle R, Lladó A, Gómez-Tortosa E, Gelpi E, Van den Broeck M, Peeters K, Cras P, De Deyn PP, Engelborghs S, Cruts M, Van Broeckhoven C; BELNEU Consortium; EU EOD Consortium25.


Patient Engagement: The Fundació ACE Framework for Improving Recruitment and Retention in Alzheimer's Disease Research

J Alzheimers Dis. 2018;62(3):1079-1090. F.I.: 3.476. doi: 10.3233/JAD-170866

Boada M, Santos-Santos MA, Rodríguez-Gómez O, Alegret M, Cañabate P, Lafuente A, Abdelnour C, Buendía M, de Dios MJ, Morera A, Sanabria Á, Campo L, Ruiz A, Tárraga L.


The Role of Verb Fluency in the Detection of Early Cognitive Impairment in Alzheimer's Disease

J Alzheimers Dis. 2018;62(2):611-619. F.I.:3.476. doi: 10.3233/JAD-170826

Alegret M, Peretó M, Pérez A, Valero S, Espinosa A, Ortega G, Hernández I, Mauleón A, Rosende-Roca M, Vargas L, Rodríguez-Gómez O, Abdelnour C, Berthier ML, Bak TH, Ruíz A, Tárraga L, Boada M.


Los genes de la esquizofrenia que protegen del alzhéimer

Mente y cerebro, ISSN 1695-0887, Nº. 88, 2018, págs. 32-35

S Moreno, A Ruiz.


Altered topology of the functional speech production network in non-fluent/agrammatic variant of PPA 

Cortex. 2018 Nov;108:252-264. F.I.: 4.90 doi: 10.1016/j.cortex.2018.08.002

Mandelli ML, Welch AE, Vilaplana E, Watson C, Battistella G, Brown JA, Possin KL, Hubbard HI, Miller ZA, Henry ML, Marx GA, Santos-Santos MA, Bajorek LP, Fortea J, Boxer A, Rabinovici G, Lee S, Deleon J, Rosen HJ, Miller BL, Seeley WW, Gorno-Tempini ML. 


Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia

Annals of Neurology. 2018 Nov;84(5):729-740. F.I.: 10.24  doi: 10.1002/ana.25333.

Bergeron D, Gorno-Tempini ML, Rabinovici GD, Santos-Santos MA, Seeley W, Miller BL, Pijnenburg Y, Keulen MA, Groot C, van Berckel BNM, van der Flier WM, Scheltens P, Rohrer JD, Warren JD, Schott JM, Fox NC, Sanchez-Valle R, Grau-Rivera O, Gelpi E, Seelaar H, Papma JM, van Swieten JC, Hodges JR, Leyton CE, Piguet O, Rogalski EJ, Mesulam MM, Koric L, Nora K, Pariente J, Dickerson B, Mackenzie IR, Hsiung GR, Belliard S, Irwin DJ, Wolk DA, Grossman M, Jones M, Harris J, Mann D, Snowden JS, Chrem-Mendez P, Calandri IL, Amengual AA, Miguet-Alfonsi C, Magnin E, Magnani G, Santangelo R, Deramecourt V, Pasquier F, Mattsson N, Nilsson C, Hansson O, Keith J, Masellis M, Black SE, Matías-Guiu JA, Cabrera-Martin MN, Paquet C, Dumurgier J, Teichmann M, Sarazin M, Bottlaender M, Dubois B, Rowe CC, Villemagne VL, Vandenberghe R, Granadillo E, Teng E, Mendez M, Meyer PT, Frings L, Lleó A, Blesa R, Fortea J, Seo SW, Diehl-Schmid J, Grimmer T, Frederiksen KS, Sánchez-Juan P, Chételat G, Jansen W, Bouchard RW, Laforce RJ, Visser PJ, Ossenkoppele R.


Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia 

JAMA Neurology. 2018 Mar 1;75(3):342-352.  F.I.; 11.46   doi: 10.1001/jamaneurol.2017.4309.

Santos-Santos MA, Rabinovici GD, Iaccarino L, Ayakta N, Tammewar G, Lobach I, Henry ML, Hubbard I, Mandelli ML, Spinelli E, Miller ZA, Pressman PS, O'Neil JP, Ghosh P, Lazaris A, Meyer M, Watson C, Yoon SJ, Rosen HJ, Grinberg L, Seeley WW, Miller BL, Jagust WJ, Gorno-Tempini ML. 

Increased Albumin Oxidation in Cerebrospinal Fluid and Plasma from Alzheimer's Disease Patients

Journal of Alzheimer’s Disease. 2018 May 16.   F.I.: 3.476   doi: 10.3233/JAD-180243.

Costa M, Horrillo R, Ortiz AM, Pérez A, Mestre A, Ruiz A, Boada M, Grancha S. 


Total Listing 11



Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer disease and three causality networks of AD: the GR@ACE project.
bioRvix. doi:10.1101/528901
Sonia Moreno-Grau, Itziar de Rojas, Isabel Hernandez, Ines Quintela, Laura Montrreal, Montserrat Alegret, Begona Olasagarre, Laura Madrid, Antonio Gonzalez, Olalla Marona, Matiee Rosende-Roca, Ana Mauleon, Liliana Vargas, Asuncion Lafuente, Carla Abdelnour, Octavio Rodriguez-Gonzalez, Silvia Gil, Miguel Angel Santos-Santos, Ana Espinosa, Gemma Ortega, Angela Sanabria, Alba Perez-Cordon, Susana Ruiz, Nuria Aguilera, Juan Antonio Pineda, Juan Macias, Emilio Alarcon-Martin, Oscar Sotolongo-Grau, GR@ACE consortium, DEGESCO consortium, Alzheimer Disease Neuroimaging Initiative, Marta Marquie, Gemma Monte-Rubio, Sergi Valero, Jordi Clarimon, Maria Jesus Bullido, Guillermo Garcia-Ribas, Pau Pastor, Pascual Sanchez-Juan, Victoria Alvarez, Gerard Pinol-Ripoll, Jose Maria Garcia-Alberca, Jose Luis Royo, Emilio Franco, Pablo Mir, Miguel Calero, Miguel Medina, Alberto Rabano, Jesus Avila, Carmen Antunez, Luis Miguel Real, Adelina Orellana, Angel Carracedo, Maria Eugenia Saez, LLuis Tarraga, Merce Boada, Agustin Ruiz.

Plasma exchange for Alzheimer's disease Management by Albumin Replacement (AMBAR) trial: Study design and progress
Alzheimers Dement (N Y). 2019 Feb 26;5:61-69. doi: 10.1016/j.trci.2019.01.001. eCollection 2019.
Boada M, López O, Núñez L, Szczepiorkowski ZM, Torres M, Grifols C, Páez A. 

Plasma Aβ42/40 Ratio Detects Early Stages of Alzheimer's Disease and Correlates with CSF and Neuroimaging Biomarkers in the AB255 Study.
J Prev Alzheimers Dis. 2019;6(1):34-41. doi: 10.14283/jpad.2018.41.
Pérez-Grijalba V1, Romero J, Pesini P, Sarasa L, Monleón I, San-José I, Arbizu J, Martínez-Lage P, Munuera J, Ruiz A, Tárraga L, Boada M, Sarasa M.

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
Nat Genet. 2019 Mar;51(3):414-430.  doi:10.1038/s41588-019-0358-2.
Kunkle BW1, Grenier-Boley B2,3,4, Sims R5,6, Bis JC7, Damotte V2,3,4, Naj AC8, Boland A9, Vronskaya M5, van der Lee SJ10, Amlie-Wolf A11, Bellenguez C2,3,4, Frizatti A5, Chouraki V2,3,4,12,13, Martin ER14, Sleegers K15,16, Badarinarayan N5, Jakobsdottir J17, Hamilton-Nelson KL14, Moreno-Grau S18,19, Olaso R9, Raybould R5,6, Chen Y20, Kuzma AB11, Hiltunen M21,22, Morgan T5, Ahmad S10, Vardarajan BN23,24,25, Epelbaum J26, Hoffmann P27,28,29, Boada M18,19, Beecham GW14, Garnier JG9, Harold D30, Fitzpatrick AL31,32, Valladares O11, Moutet ML9, Gerrish A33, Smith AV34,35, Qu L11, Bacq D9, Denning N5,6, Jian X36, Zhao Y11, Del Zompo M37, Fox NC33,38, Choi SH18, Mateo I39, Hughes JT40, Adams HH10, Malamon J11, Sanchez-Garcia F41, Patel Y40, Brody JA7, Dombroski BA11, Naranjo MCD41, Daniilidou M42, Eiriksdottir G17, Mukherjee S43, Wallon D44, Uphill J45, Aspelund T17,46, Cantwell LB11, Garzia F9, Galimberti D47,48, Hofer E49,50, Butkiewicz M51, Fin B9, Scarpini E47,48, Sarnowski C20, Bush WS51, Meslage S9, Kornhuber J52, White CC53, Song Y51, Barber RC54, Engelborghs S55,56, Sordon S57, Voijnovic D10, Adams PM58, Vandenberghe R59, Mayhaus M57, Cupples LA12,20, Albert MS60, De Deyn PP55,56, Gu W57, Himali JJ12,13,20, Beekly D61, Squassina A37, Hartmann AM62, Orellana A18, Blacker D63,64, Rodriguez-Rodriguez E39, Lovestone S65, Garcia ME66, Doody RS67, Munoz-Fernadez C41, Sussams R68, Lin H69, Fairchild TJ70, Benito YA41, Holmes C68, Karamujić-Čomić H10, Frosch MP71, Thonberg H72,73, Maier W74,75, Roschupkin G10, Ghetti B76, Giedraitis V77, Kawalia A78, Li S20, Huebinger RM79, Kilander L77, Moebus S80, Hernández I18,19, Kamboh MI81,82,83, Brundin R77, Turton J84, Yang Q20, Katz MJ85, Concari L86,87, Lord J84, Beiser AS12,13,20, Keene CD88, Helisalmi S21,22, Kloszewska I89, Kukull WA32, Koivisto AM21,22, Lynch A90,91, Tarraga L18,19, Larson EB92, Haapasalo A93, Lawlor B90,91, Mosley TH94, Lipton RB85, Solfrizzi V95, Gill M90,91, Longstreth WT Jr32,96, Montine TJ88, Frisardi V97, Diez-Fairen M98,99, Rivadeneira F10,100,101, Petersen RC102, Deramecourt V103, Alvarez I98,99, Salani F104, Ciaramella A104, Boerwinkle E105,106, Reiman EM107,108,109,110, Fievet N2,3,4, Rotter JI111, Reisch JS112, Hanon O113, Cupidi C114, Andre Uitterlinden AG10,100,101, Royall DR115, Dufouil C116,117, Maletta RG114, de Rojas I18,19, Sano M118, Brice A119,120, Cecchetti R121, George-Hyslop PS122,123, Ritchie K124,125,126, Tsolaki M42, Tsuang DW127,128, Dubois B129,130,131,132, Craig D133, Wu CK134, Soininen H21,22, Avramidou D42, Albin RL135,136,137, Fratiglioni L138, Germanou A42, Apostolova LG139,140,141,142, Keller L138, Koutroumani M42, Arnold SE143, Panza F97, Gkatzima O42, Asthana S144,145,146, Hannequin D40, Whitehead P14, Atwood CS140,141,142, Caffarra P83,84, Hampel H147,148,149,150, Quintela I151, Carracedo Á151, Lannfelt L77, Rubinsztein DC122,152, Barnes LL153,154,155, Pasquier F103, Frölich L156, Barral S23,24,25, McGuinness B133, Beach TG157, Johnston JA133, Becker JT81,158,159, Passmore P133, Bigio EH160,161, Schott JM33, Bird TD96,127, Warren JD33, Boeve BF102, Lupton MK40,162, Bowen JD163, Proitsi P40, Boxer A164, Powell JF40, Burke JR165, Kauwe JSK166, Burns JM167, Mancuso M168, Buxbaum JD118,169,170, Bonuccelli U168, Cairns NJ171, McQuillin A172, Cao C173, Livingston G172, Carlson CS145,146, Bass NJ172, Carlsson CM174, Hardy J175, Carney RM176, Bras J38,177, Carrasquillo MM178, Guerreiro R38,177, Allen M178, Chui HC179, Fisher E177, Masullo C180, Crocco EA181, DeCarli C182, Bisceglio G178, Dick M183, Ma L178, Duara R184, Graff-Radford NR178, Evans DA185, Hodges A186, Faber KM139, Scherer M187, Fallon KB188, Riemenschneider M57, Fardo DW189, Heun R75, Farlow MR141, Kölsch H75, Ferris S190, Leber M191, Foroud TM139, Heuser I192, Galasko DR193, Giegling I62, Gearing M194,195, Hüll M196, Geschwind DH197, Gilbert JR14, Morris J198,199, Green RC200, Mayo K198,201,202, Growdon JH203, Feulner T57, Hamilton RL204, Harrell LE205, Drichel D206, Honig LS23, Cushion TD5,6, Huentelman MJ107, Hollingworth P5, Hulette CM207, Hyman BT203, Marshall R5, Jarvik GP208,209, Meggy A5, Abner E210, Menzies GE5,6, Jin LW211, Leonenko G5, Real LM211, Jun GR212, Baldwin CT212, Grozeva D5, Karydas A163, Russo G213, Kaye JA214,215, Kim R216, Jessen F74,75,191, Kowall NW13,217, Vellas B218, Kramer JH219, Vardy E220, LaFerla FM221, Jöckel KH80, Lah JJ222, Dichgans M223,224, Leverenz JB225, Mann D226, Levey AI222, Pickering-Brown S226, Lieberman AP227, Klopp N228, Lunetta KL20, Wichmann HE229,230,231, Lyketsos CG232, Morgan K233, Marson DC205, Brown K84, Martiniuk F234, Medway C84, Mash DC235, Nöthen MM27,28, Masliah E193,236, Hooper NM226, McCormick WC43, Daniele A237, McCurry SM238, Bayer A239, McDavid AN173, Gallacher J65, McKee AC13,217, van den Bussche H187, Mesulam M161,240, Brayne C241, Miller BL242, Riedel-Heller S243, Miller CA244, Miller JW245, Al-Chalabi A246, Morris JC171,201, Shaw CE246,247, Myers AJ181, Wiltfang J248,249,250, 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The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease.
Mol Psychiatry. 2019 Mar 21. doi: 10.1038/s41380-019-0404-6.
Franzmeier N, Ren J, Damm A, Monté-Rubio G, Boada M, Ruiz A, Ramirez A, Jessen F, Düzel E, Rodríguez Gómez O, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, Buerger K, Levin J, Duering M, Dichgans M, Suárez-Calvet M, Haass C, Gordon BA, Lim YY, Masters CL, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Milz E, Moreno-Grau S, Teipel S, Grothe MJ, Kilimann I, Rossor M, Fox N, Laske C, Chhatwal J, Falkai P, Perneczky R, Lee JH, Spottke A, Boecker H, Brosseron F, Fliessbach K, Heneka MT, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero MÁ, Metzger C, Bittner D, Salloway S, Danek A, Hassenstab J, Yakushev I, Schofield PR, Morris JC, Bateman RJ, Ewers M.

Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia.
Alzheimers Dement. 2019 Mar;15(3):465-476. doi: 10.1016/j.jalz.2018.10.003.
Slot RER, Sikkes SAM, Berkhof J, Brodaty H, Buckley R, Cavedo E, Dardiotis E, Guillo-Benarous F, Hampel H, Kochan NA, Lista S, Luck T, Maruff P, Molinuevo JL, Kornhuber J, Reisberg B, Riedel-Heller SG, Risacher SL, Roehr S, Sachdev PS, Scarmeas N, Scheltens P, Shulman MB, Saykin AJ, Verfaillie SCJ, Visser PJ, Vos SJB, Wagner M, Wolfsgruber S, Jessen F; Alzheimer's Disease Neuroimaging Initiative; DESCRIPA working group; INSIGHT-preAD study group; SCD-I working group, van der Flier WM.

Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease.
N Engl J Med 2019; 380:1408-1420. doi: 10.1056/NEJMoa1812840.
Michael F. Egan, M.D., James Kost, Ph.D., Tiffini Voss, M.D., Yuki Mukai, M.D., Paul S. Aisen, M.D., Jeffrey L. Cummings, M.D., Sc.D., Pierre N. Tariot, M.D., Bruno Vellas, M.D., Ph.D., Christopher H. van Dyck, M.D., Merce Boada, M.D., Ying Zhang, Ph.D., Wen Li, Ph.D., Christine Furtek, B.S., Erin Mahoney, B.A., Lyn Harper Mozley, Ph.D., Yi Mo, Ph.D., Cyrille Sur, Ph.D., and David Michelson, M.D.

Cross-Sectional Characterization of Albumin Glycation State in Cerebrospinal Fluid and Plasma from Alzheimer’s Disease Patients.
J Prev Alzheimers Dis. 2019;6(2):139-143. doi:10.14283/jpad.2018.48.
Costa M, Mestre A, Horrillo R, Ortiz AM, Pérez A, Ruiz A, Boada M, Grancha S.

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.
Nat Med. 2019 Jan;25(1):152-164. doi: 10.1038/s41591-018-0223-3.
Swarup V, Hinz FI, Rexach JE, Noguchi KI, Toyoshiba H, Oda A, Hirai K, Sarkar A, Seyfried NT, Cheng C, Haggarty SJ; International Frontotemporal Dementia Genomics Consortium, Grossman M, Van Deerlin VM, Trojanowski JQ, Lah JJ, Levey AI, Kondou S, Geschwind DH.

The MOPEAD project: Advancing patient engagement for the detection of “hidden” undiagnosed cases of Alzheimer's disease in the community.
Alzheimers Dement. 2019 May 6. doi: 10.1016.
Octavio Rodríguez, Adrián Rodrigo, Fátima Iradier, Miguel A. Santos-Santos, Hans Hundemer, Andreea Ciudin, Lena Sannemann, Marissa Zwan, Bridget Glaysher, Anders Wimo, Jaka Bonn, Gunilla Johansson, Isabel Rodriguez, Montse Alegret, Dianne Govel, Susana Pinó, Paloma Trigueros, Miia Kivipelto, Brandy Mathews, Antonio Ciudad, Daniel Ferreira, Christophe Bintener, Miren Gurruchaga, Eric Westman, Mark Belger, Sergi Valero, Peggy Maguire, David Krivec, Milica Kramberger, Rafael Simó, Inmaculada Pérez Garro, Pieter Jelle Visserh, Annette Dumas, Jean Georges, Frank Jessen, Bengt Winblad, Craig Shering, Neil Stewart, Laura Campo, Mercè Boada on behalf of the MOPEAD Consortium
Relevance of the interplay between amyloid and tau for cognitive impairment in early Alzheimer's disease.
Neurobiol Aging. 2019 Apr 1; doi: 10.1016.
Maarten Timmers, Ina Tesseur, Jennifer Bogert, Henrik Zetterberg, Kaj Blennow, Anne Börjesson-Hanson, Miquel Baquero, Mercè Boada, Christopher Randolph, Luc Tritsmans, LucVan Nueten, Sebastiaan Engelborgh, Johannes RolfStreffer.